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Entry: H1YWS0_9EURY
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ID   H1YWS0_9EURY            Unreviewed;       333 AA.
AC   H1YWS0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=5,10-methylenetetrahydromethanopterin reductase {ECO:0000256|HAMAP-Rule:MF_01091};
DE            EC=1.5.98.2 {ECO:0000256|HAMAP-Rule:MF_01091};
DE   AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase {ECO:0000256|HAMAP-Rule:MF_01091};
DE   AltName: Full=Methylene-H(4)MPT reductase {ECO:0000256|HAMAP-Rule:MF_01091};
GN   Name=mer {ECO:0000256|HAMAP-Rule:MF_01091};
GN   ORFNames=Metlim_2776 {ECO:0000313|EMBL:EHQ36811.1};
OS   Methanoplanus limicola DSM 2279.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoplanus.
OX   NCBI_TaxID=937775 {ECO:0000313|EMBL:EHQ36811.1, ECO:0000313|Proteomes:UP000005741};
RN   [1] {ECO:0000313|EMBL:EHQ36811.1, ECO:0000313|Proteomes:UP000005741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2279 {ECO:0000313|EMBL:EHQ36811.1,
RC   ECO:0000313|Proteomes:UP000005741};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Wirth R., Brambilla E.-M., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The Improved High-Quality Draft genome of Methanoplanus limicola DSM
RT   2279.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible reduction of methylene-H(4)MPT to
CC       methyl-H(4)MPT. {ECO:0000256|HAMAP-Rule:MF_01091}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + H(+) + oxidized
CC         coenzyme F420-(gamma-L-Glu)(n) = 5,10-
CC         methylenetetrahydromethanopterin + reduced coenzyme F420-(gamma-L-
CC         Glu)(n); Xref=Rhea:RHEA:21144, Rhea:RHEA-COMP:12939, Rhea:RHEA-
CC         COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58116,
CC         ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.2;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01091};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC       coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC       1/2. {ECO:0000256|HAMAP-Rule:MF_01091}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01091}.
CC   -!- SIMILARITY: Belongs to the mer family. {ECO:0000256|HAMAP-
CC       Rule:MF_01091}.
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DR   EMBL; CM001436; EHQ36811.1; -; Genomic_DNA.
DR   RefSeq; WP_004079454.1; NZ_CM001436.1.
DR   AlphaFoldDB; H1YWS0; -.
DR   STRING; 937775.Metlim_2776; -.
DR   PATRIC; fig|937775.9.peg.3119; -.
DR   HOGENOM; CLU_027853_5_3_2; -.
DR   InParanoid; H1YWS0; -.
DR   OrthoDB; 213164at2157; -.
DR   UniPathway; UPA00640; UER00697.
DR   Proteomes; UP000005741; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018537; F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01097; Tetrahydromethanopterin_reductase; 1.
DR   Gene3D; 3.20.20.30; Luciferase-like domain; 1.
DR   HAMAP; MF_01091; F420_mer; 1.
DR   InterPro; IPR011251; Luciferase-like_dom.
DR   InterPro; IPR036661; Luciferase-like_sf.
DR   InterPro; IPR019946; MeH4methanopterin_reductase.
DR   NCBIfam; TIGR03555; F420_mer; 1.
DR   PANTHER; PTHR43244; -; 1.
DR   PANTHER; PTHR43244:SF1; 5,10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE; 1.
DR   Pfam; PF00296; Bac_luciferase; 1.
DR   SUPFAM; SSF51679; Bacterial luciferase-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01091};
KW   Methanogenesis {ECO:0000256|HAMAP-Rule:MF_01091};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563, ECO:0000256|HAMAP-
KW   Rule:MF_01091}; Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005741}.
FT   DOMAIN          12..310
FT                   /note="Luciferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00296"
SQ   SEQUENCE   333 AA;  35379 MW;  A9A4F562D6278DC1 CRC64;
     MSYGIEFVPG NISVKQVVNY CKLAEQKDID FAWITNHYNN RHCYPTLAAI AQATDSIKMG
     PGIMNTFTDT PAAIASFMCT LNEISEGRAV LGIGPGDLST LPKLAIEASK PVARLAEGVK
     QIKALCAGEE VKKTGDMEFF DYDGAKLTGV QLPAKKKQIP TYIGAQGPKM LALAGEIGDG
     ALINASNSKD FDIAIPLIKA ACDAVDEKKF KKFDVGAYTA MSIDQNEKKA RNAAKIVAAF
     IAAGSPPALL ERHGLDLNNV AKIKEALGRF DFGAVGGLVG DAEIDAFTIA GTPEMVKEKC
     ENLTASGVTQ IIFGSPLGPD MTNSIRLLGK YII
//
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