UniProt: H1Z2D8

Database: UniProt
Entry: H1Z2D8_9EURY

LinkDB:  H1Z2D8_9EURY 
Original site:  H1Z2D8_9EURY

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (6)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (1)   
All databases (13)   

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ID   H1Z2D8_9EURY            Unreviewed;       371 AA.
AC   H1Z2D8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=tRNA (guanine(26)-N(2))-dimethyltransferase {ECO:0000256|ARBA:ARBA00039099, ECO:0000256|HAMAP-Rule:MF_00290};
DE            EC=2.1.1.216 {ECO:0000256|ARBA:ARBA00039099, ECO:0000256|HAMAP-Rule:MF_00290};
DE   AltName: Full=tRNA 2,2-dimethylguanosine-26 methyltransferase {ECO:0000256|HAMAP-Rule:MF_00290};
DE   AltName: Full=tRNA(guanine-26,N(2)-N(2)) methyltransferase {ECO:0000256|HAMAP-Rule:MF_00290};
DE   AltName: Full=tRNA(m(2,2)G26)dimethyltransferase {ECO:0000256|HAMAP-Rule:MF_00290};
GN   Name=trm1 {ECO:0000256|HAMAP-Rule:MF_00290};
GN   ORFNames=Metlim_0532 {ECO:0000313|EMBL:EHQ34667.1};
OS   Methanoplanus limicola DSM 2279.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoplanus.
OX   NCBI_TaxID=937775 {ECO:0000313|EMBL:EHQ34667.1, ECO:0000313|Proteomes:UP000005741};
RN   [1] {ECO:0000313|EMBL:EHQ34667.1, ECO:0000313|Proteomes:UP000005741}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 2279 {ECO:0000313|EMBL:EHQ34667.1,
RC   ECO:0000313|Proteomes:UP000005741};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA   Hugenholtz P., Woyke T., Wu D., Wirth R., Brambilla E.-M., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The Improved High-Quality Draft genome of Methanoplanus limicola DSM
RT   2279.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Dimethylates a single guanine residue at position 26 of a
CC       number of tRNAs using S-adenosyl-L-methionine as donor of the methyl
CC       groups. {ECO:0000256|HAMAP-Rule:MF_00290}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = 2 H(+) +
CC         N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43140, Rhea:RHEA-COMP:10359, Rhea:RHEA-COMP:10360,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74513; EC=2.1.1.216;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00290};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family. {ECO:0000256|HAMAP-Rule:MF_00290,
CC       ECO:0000256|PROSITE-ProRule:PRU00958}.
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DR   EMBL; CM001436; EHQ34667.1; -; Genomic_DNA.
DR   RefSeq; WP_004076338.1; NZ_CM001436.1.
DR   AlphaFoldDB; H1Z2D8; -.
DR   STRING; 937775.Metlim_0532; -.
DR   PATRIC; fig|937775.9.peg.624; -.
DR   HOGENOM; CLU_010862_5_1_2; -.
DR   InParanoid; H1Z2D8; -.
DR   OrthoDB; 372177at2157; -.
DR   Proteomes; UP000005741; Chromosome.
DR   GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0160104; F:tRNA (guanine(26)-N2)-dimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.30.56.70; N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   HAMAP; MF_00290; tRNA_dimethyltr_TRM1; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002905; Trm1.
DR   InterPro; IPR022923; TRM1_arc_bac.
DR   InterPro; IPR042296; tRNA_met_Trm1_C.
DR   NCBIfam; TIGR00308; TRM1; 1.
DR   PANTHER; PTHR10631; N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10631:SF3; TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE; 1.
DR   Pfam; PF02005; TRM; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51626; SAM_MT_TRM1; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW   Rule:MF_00290}; Reference proteome {ECO:0000313|Proteomes:UP000005741};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00958};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW   Rule:MF_00290};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00290};
KW   tRNA processing {ECO:0000256|HAMAP-Rule:MF_00290, ECO:0000256|PROSITE-
KW   ProRule:PRU00958};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|PROSITE-
KW   ProRule:PRU00958}.
SQ   SEQUENCE   371 AA;  41448 MW;  92AFE6B7C0F8FDC8 CRC64;
     MDLVEVTEGT TKFLVPKQDN TEKFPPGTAP VFFNRRMEIN RDITVLLMKC LSPSTYLDAM
     GATGVRGFRA AHECGIETTI NEKDSDAVAL LEYNSETYCR NIEVVHSDAK VIMNERRFDA
     VDVDPFGSPA PFLDSASGCA KRFLFATATD TAPLCGAHLK AGIRRYAARP LNTDYHSEVG
     LRILLGYALR EAAKYDRGIE PLFSFAREHF VRIHLKMTNG AGRADKALEN LGYIHQCPKC
     PYREEEKAVL PERRTCPDCG ARLTPAGPLW LGAVSDTGII RQMTEILPET ELGSKNQIEK
     LLNTCMNELP SSTFYDYHRL AKTWRVSPKA IDTVIEELIN SGWKASRVHY AGTGIKTDAP
     LKEIKEILCR R
//

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