ID H1Z4B1_9EURY Unreviewed; 373 AA.
AC H1Z4B1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:EHQ36659.1};
GN ORFNames=Metlim_2618 {ECO:0000313|EMBL:EHQ36659.1};
OS Methanoplanus limicola DSM 2279.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoplanus.
OX NCBI_TaxID=937775 {ECO:0000313|EMBL:EHQ36659.1, ECO:0000313|Proteomes:UP000005741};
RN [1] {ECO:0000313|EMBL:EHQ36659.1, ECO:0000313|Proteomes:UP000005741}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2279 {ECO:0000313|EMBL:EHQ36659.1,
RC ECO:0000313|Proteomes:UP000005741};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Lu M.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Wirth R., Brambilla E.-M., Klenk H.-P.,
RA Eisen J.A.;
RT "The Improved High-Quality Draft genome of Methanoplanus limicola DSM
RT 2279.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CM001436; EHQ36659.1; -; Genomic_DNA.
DR RefSeq; WP_004079142.1; NZ_CM001436.1.
DR AlphaFoldDB; H1Z4B1; -.
DR STRING; 937775.Metlim_2618; -.
DR PATRIC; fig|937775.9.peg.2948; -.
DR HOGENOM; CLU_042889_0_0_2; -.
DR InParanoid; H1Z4B1; -.
DR OrthoDB; 2305at2157; -.
DR Proteomes; UP000005741; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR023980; CHP04013_B12-bd/rSAM.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR020612; Methylthiotransferase_CS.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04013; B12_SAM_MJ_1487; 1.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS01278; MTTASE_RADICAL; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000005741}.
FT DOMAIN 133..363
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 373 AA; 41769 MW; B31D88AD81F15D4E CRC64;
MKINWRNIKW AGNSYAALYA ACELAGYELI PVDKPEDDIT LYSLNSVNAD HFSDEIRNAE
CITVAGGPHP SADHKQFTGI ADYVVVGEAE YSLPALLRYL DPDSPEKDLP AGVAAGDRYR
EKDYCVIPDA YPPFTKIKGY VEISRGCPYG CAYCQTPRLF GQGIRHRSID CIVKAASGYR
DVRFISPNSL AYGSKTGTSP DYDKLEKLLS SFFSDQNVYL GTFPSEVRPE FVTEKSLELI
SDYCSNKKIH FGAQSGSNRM LRKIRRGHTS EDVVSAVELC REFGFTPVVD YIIGLPGEEE
EDQRETLEQI KWVCRYGKVH SHYFTPLSGT PFEGEKPAPL IPDVNRILGK LSLNGKVTGY
WIESGSRFFN QNK
//
