ID H2AN92_KAZAF Unreviewed; 645 AA.
AC H2AN92;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=KAFR0A04070 {ECO:0000313|EMBL:CCF55842.1};
GN ORFNames=KAFR_0A04070 {ECO:0000313|EMBL:CCF55842.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF55842.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF55842.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR EMBL; HE650821; CCF55842.1; -; Genomic_DNA.
DR RefSeq; XP_003954977.1; XM_003954928.1.
DR AlphaFoldDB; H2AN92; -.
DR STRING; 1071382.H2AN92; -.
DR GeneID; 13886422; -.
DR KEGG; kaf:KAFR_0A04070; -.
DR eggNOG; KOG0590; Eukaryota.
DR HOGENOM; CLU_000288_82_2_1; -.
DR InParanoid; H2AN92; -.
DR OrthoDB; 5318028at2759; -.
DR Proteomes; UP000005220; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24343; SERINE/THREONINE KINASE; 1.
DR PANTHER; PTHR24343:SF565; SERINE_THREONINE-PROTEIN KINASE HRK1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT DOMAIN 215..612
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 250
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 645 AA; 73112 MW; 1D4D8DECB0691AEE CRC64;
MPLLSRKSFH HNHDSEKPDE QNGSRPNPPL KRSSKSFLSF MSRKPSTDSI RSDKSNDSFV
THSNNNSSSN LSVLSPPHNN HHHYNTKLHG HDIDSHLAVS PKQSHSMLEL KRFFRSKKLT
TRTHNNNLNS NHGTNGSNHS SAPATRTGSR SFSDHHPYST TQLNLNAHYD AVHHTDANHN
SHTHSAIPPS SDSVLSLANT INIYHDDTIL ATKYGKVGKT LGSGAGGSVK IITRPTDGVM
FAVKEFRPRK PNESIKQYAK KCTAEFCIGS SLHHANVVET IDIFSDFNQN KYFEVMEYLP
IDFFGVVMTG QMSRGEINCC FRQILEGVKY LHSMGLAHRD LKLDNCCMTQ DGILKLIDFG
SAVVFQYPFE PDSDVQMAHG IVGSDPYLAP EAITSSKCYD PQFVDIWSVG IIYCCMMLKR
FPWKAPKQSD ENFKLYAMQD DMEHDYIQSA KHHEQLLKER RDRHNIIKEH PHDNATTDNN
TTITTTSGVN KSTSHNNDKT INNDNTAAAM QQLPTPPHEN NVPKEHNDTD DNIKIETNNK
NNDNDTKEND IKPTESHPDS KHSKARHKKT IHGPYRLLRL LPHASRPIMS RILEIDVEKR
ATLNEIFTDE WFKAIPYCSM DEKKSVVRAT GHHHTIFKDD KTYKI
//
