ID   H2ANH1_KAZAF            Unreviewed;       462 AA.
AC   H2ANH1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   13-SEP-2023, entry version 40.
DE   RecName: Full=Checkpoint protein {ECO:0008006|Google:ProtNLM};
GN   Name=KAFR0A04850 {ECO:0000313|EMBL:CCF55921.1};
GN   ORFNames=KAFR_0A04850 {ECO:0000313|EMBL:CCF55921.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF55921.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF55921.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR   EMBL; HE650821; CCF55921.1; -; Genomic_DNA.
DR   RefSeq; XP_003955056.1; XM_003955007.1.
DR   AlphaFoldDB; H2ANH1; -.
DR   STRING; 1071382.H2ANH1; -.
DR   GeneID; 13886049; -.
DR   KEGG; kaf:KAFR_0A04850; -.
DR   eggNOG; ENOG502RA7D; Eukaryota.
DR   HOGENOM; CLU_597417_0_0_1; -.
DR   InParanoid; H2ANH1; -.
DR   OrthoDB; 2034080at2759; -.
DR   Proteomes; UP000005220; Chromosome 1.
DR   GO; GO:0030896; C:checkpoint clamp complex; IEA:InterPro.
DR   GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:InterPro.
DR   Gene3D; 3.70.10.10; -; 1.
DR   InterPro; IPR007150; Hus1/Mec3.
DR   PANTHER; PTHR12900:SF0; CHECKPOINT PROTEIN; 1.
DR   PANTHER; PTHR12900; MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1; 1.
DR   Pfam; PF04005; Hus1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT   REGION          349..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51830 MW;  4402C92CC5EDD748 CRC64;
     MKLKLIINAL EAPDDYKLLR TTISTVASLR KTAILRFTEE KLVIISSPQI AANASNNNAV
     LTGDSGQLWC SIPRDVFSFY QVVSTREQNT ITLEYSCDSF LSVLKRYDRA MNQGSISDMS
     IKLQAMPEWN PPNESATSNG TARPKQGFVC ALGISFEEIV HTNNAAVGNE PNDIDDGLGM
     IAKSTVMGNN RLILHSFKIP VKLLVRSQDA RIKEPTINSE QLIMFKLPPT SSELGGSFHN
     FMKRIERYSN LHDIKLSAIK KNQRNINDAD AIKFKMIVDE LDWYLEICWN GPLDPIFPHD
     PESEKLNQGE TAQNSHPIYA EHDTFESAPS EPLPSRSYAE EEYYPSRIED SETSCTTNNS
     TMREESATEN GRGAQLADVS TMVELAEQES SSTYEVKIRS KDWKVCSKLY VAFQEVSLLV
     SHNDSCVFHC SLDRGSIDDS NGDEIDREKG HIIYYIARSK AL
//