ID H2ANT6_KAZAF Unreviewed; 872 AA.
AC H2ANT6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 03-MAY-2023, entry version 57.
DE RecName: Full=Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein {ECO:0000259|Pfam:PF11916};
GN Name=KAFR0A06010 {ECO:0000313|EMBL:CCF56036.1};
GN ORFNames=KAFR_0A06010 {ECO:0000313|EMBL:CCF56036.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF56036.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF56036.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE650821; CCF56036.1; -; Genomic_DNA.
DR RefSeq; XP_003955171.1; XM_003955122.1.
DR AlphaFoldDB; H2ANT6; -.
DR STRING; 1071382.H2ANT6; -.
DR GeneID; 13886371; -.
DR KEGG; kaf:KAFR_0A06010; -.
DR eggNOG; KOG0212; Eukaryota.
DR HOGENOM; CLU_007740_0_0_1; -.
DR InParanoid; H2ANT6; -.
DR OrthoDB; 5481081at2759; -.
DR Proteomes; UP000005220; Chromosome 1.
DR GO; GO:0070772; C:PAS complex; IEA:InterPro.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 87..125
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 563..737
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 843..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 271..305
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 872 AA; 98593 MW; F68038D4C52A8C58 CRC64;
MDKTIAKGLS DKLYEKRKAT ALQLEKLVKT CVQEGDYTRI DGIIGELCRD YAYALHQPMA
RNAGLMGLAA TAIALGTNDV SKYLRSILPP VLACFGDQND QVRFYACESL YNIAKIAKGE
ILLHFNEIFD VLCKISADTE NSVRGAAELL DRLIKDIVAE RASNYVAIVN NDPHDVPLAT
RSDSLTGNVY QESYKQDNNL AFSLPKFIPL LTERIYAINP DTRVFLVDWI KVLLNAPGLE
LISFLPSFLG GLFVFLGDSH KDVRNVTHAL IDLLLHEIKR ISALKEELRK QHNDQLKLLE
EKNEAPAKKE DGMLIAEKKK SLISAFGELS MENTPVAQET VNFDAGSHPP SITAAREMTL
KEDLRNGEEY TPGQDVHLNF PEIIRILVNN LTSSEPEIQS LSLHWMSSIL AISPNDFLPF
FPKILSSLMN LLSEPNTHIT ELAQTVNKRL LLLCTEYVKS TKDKPIAYGS IVNNLTLQFF
DSKVETKIAC LDWLSLIYNK APDEILEHND SMFLTLLKSL SDKDSKLIEK AMGFLKSLCS
ASNDNYLRKF LEEFLNLLRR DSRLLKDRAN NIVRKVCTSL PPERVFKVIS SILSSYDDIT
FVRMMIQILS TNLLISPEMF SLRRKLRCAD DMMFFNLLFK SWCHNPISVI SLCLVSENYE
LAYSVIQAYA NFDLKLNDLL QLDVLVQLFE SPVFTRMRLQ LLEPQNHPFL YKCLYGLLMI
LPQSKAFDSL NKRLTSVNIW ASQPVYPGTY HKARNISGSL SDPDVSQRSV SQSKLHVQEL
IDYFTMIVSA SVPESAYVNY TESVLPYFGN TYNTQEDYSI QSVNPVKSQF IPELEKSTES
AQFLEQPTDS GSAKFRTSSL LSNDREITDS IG
//
