ID H2AS68_KAZAF Unreviewed; 613 AA.
AC H2AS68;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=HSF-type DNA-binding domain-containing protein {ECO:0000259|PROSITE:PS00434};
GN Name=KAFR0C02250 {ECO:0000313|EMBL:CCF57218.1};
GN ORFNames=KAFR_0C02250 {ECO:0000313|EMBL:CCF57218.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF57218.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF57218.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the HSF family. {ECO:0000256|RuleBase:RU004020}.
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DR EMBL; HE650823; CCF57218.1; -; Genomic_DNA.
DR RefSeq; XP_003956353.1; XM_003956304.1.
DR AlphaFoldDB; H2AS68; -.
DR STRING; 1071382.H2AS68; -.
DR GeneID; 13885137; -.
DR KEGG; kaf:KAFR_0C02250; -.
DR eggNOG; KOG0627; Eukaryota.
DR HOGENOM; CLU_017670_1_0_1; -.
DR InParanoid; H2AS68; -.
DR OrthoDB; 1117127at2759; -.
DR Proteomes; UP000005220; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000232; HSF_DNA-bd.
DR InterPro; IPR027725; HSF_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10015:SF206; HEAT SHOCK FACTOR PROTEIN; 1.
DR PANTHER; PTHR10015; HEAT SHOCK TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00447; HSF_DNA-bind; 1.
DR PRINTS; PR00056; HSFDOMAIN.
DR SMART; SM00415; HSF; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00434; HSF_DOMAIN; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT DOMAIN 191..215
FT /note="HSF-type DNA-binding"
FT /evidence="ECO:0000259|PROSITE:PS00434"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 70360 MW; 5F7C9D425FDC27C2 CRC64;
MNNGKQDTNS NELSLLNDEE IDQILHQNNI FPDEIILPPN DTPTTTTESI QRQKDTDEIN
DIINPSIIDI PRDVQDRSLT LARDASNIYH PATTDLIRRP TTPLQNSFQR PLPADQLYSS
RILEQNSNYE MSNLTSSTQQ RRYHPHKSRP AFVNKLWSML NDNSNLDLIQ WSNDGKSFVV
TNREQFVHEI LPKYFKHSNF ASFVRQLNMY GWHKVQDVKS GSIQNSSDEK WQFENEYFQR
DREDLLEKIV RQKSNSNNTT SKEKIMNTKP ILHLMNEPST GLDNTIDING GSTTTDHVSK
VLNELEAIKY NQLAISKDLL RINKDNELLW KENMMARERY RSQQQTLEKI FRFLASIMPQ
KMIMDGVMNN SDNTNSSIDL NSLRNKGNSD NNNSESMNTN INEKNLFDEL VNNEGNNNNS
NNNNYDTLNR ASSPLRPQPR YLLKNRSNKG QSMTTTPTSA ATSSSPNKIL ELNDDDNMHP
IVEEYDTNEN ETNRGNASDD SLEFLNNLQS NISEQDNRIQ HLEDIIIQEF SPKNNVMHAN
ASNNNGNSNT ADFSLHDYFN SDAIPNSPIG ESDEGSKYKR YIEEISDDES RHLHDDATTT
TTSTANIKKP RRS
//
