ID   H2ATL0_KAZAF            Unreviewed;       501 AA.
AC   H2ATL0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF03372};
GN   Name=KAFR0D00630 {ECO:0000313|EMBL:CCF57710.1};
GN   ORFNames=KAFR_0D00630 {ECO:0000313|EMBL:CCF57710.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF57710.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF57710.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC       {ECO:0000256|ARBA:ARBA00004760}.
CC   -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the neutral sphingomyelinase family.
CC       {ECO:0000256|ARBA:ARBA00006335}.
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DR   EMBL; HE650824; CCF57710.1; -; Genomic_DNA.
DR   RefSeq; XP_003956845.1; XM_003956796.1.
DR   AlphaFoldDB; H2ATL0; -.
DR   STRING; 1071382.H2ATL0; -.
DR   GeneID; 13885668; -.
DR   KEGG; kaf:KAFR_0D00630; -.
DR   eggNOG; KOG3873; Eukaryota.
DR   HOGENOM; CLU_034001_5_0_1; -.
DR   InParanoid; H2ATL0; -.
DR   OrthoDB; 50235at2759; -.
DR   Proteomes; UP000005220; Chromosome 4.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0043603; P:amide metabolic process; IEA:UniProt.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR038772; Sph/SMPD2-like.
DR   PANTHER; PTHR16320:SF1; ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01540); 1.
DR   PANTHER; PTHR16320; SPHINGOMYELINASE FAMILY MEMBER; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        412..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          50..345
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
SQ   SEQUENCE   501 AA;  56927 MW;  474A1162A262061E CRC64;
     MQEKLSYVKL LNTKPGSHHW HMSTISIDDD ISLSLSRKQT HSQYPTIKFL TFNTWGLKFV
     SKHRKERLKA IADKLAGIRT GVPLPNLESL RDSPDLNTED TYDVVVLQEI WCKDDWDYLV
     YRCKDVFPFY RIFYSGIISG PGLAILSKIP IDSTFLHKFP INGVPSAITR GDWFVGKSIS
     VTILKALTED TAPLAILNSH MHAPYALTGE NAYYCHRSCQ AWHFSKIANL YKKAGYAVVI
     VGDLNSRPGS LPHTFLTLET GLIDSWEQLN GKQDQGEISK MNPSDQLIFG CTTCDSTLNT
     WRSKKRPDEA CRLDYALVDP AKLQTIEAGL RFTERIPNVG SFSDHFAYSC SLRFLPQDIG
     LNPVLRNKIY SNSDLNLTRD QLLEKFSTYE ELKLTIASYT KVAKRRKLIR GAYFWIAIYL
     LITSITVTSF TSQRAGWSSV FWVIFAIIVS VFGTINGLIS FLFGRSELRA LMEIEHEVTD
     AERNLQSVLD MKRTSFILPQ N
//