ID   H2AUN9_KAZAF            Unreviewed;      1345 AA.
AC   H2AUN9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=VASt domain-containing protein {ECO:0000259|PROSITE:PS51778};
GN   Name=KAFR0D04410 {ECO:0000313|EMBL:CCF58089.1};
GN   ORFNames=KAFR_0D04410 {ECO:0000313|EMBL:CCF58089.1};
OS   Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS   1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF58089.1, ECO:0000313|Proteomes:UP000005220};
RN   [1] {ECO:0000313|EMBL:CCF58089.1, ECO:0000313|Proteomes:UP000005220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC   NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the YSP2 family.
CC       {ECO:0000256|ARBA:ARBA00006582}.
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DR   EMBL; HE650824; CCF58089.1; -; Genomic_DNA.
DR   RefSeq; XP_003957224.1; XM_003957175.1.
DR   GeneID; 13882413; -.
DR   KEGG; kaf:KAFR_0D04410; -.
DR   eggNOG; KOG1032; Eukaryota.
DR   HOGENOM; CLU_002908_0_0_1; -.
DR   InParanoid; H2AUN9; -.
DR   OrthoDB; 45896at2759; -.
DR   Proteomes; UP000005220; Chromosome 4.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 1.
DR   Pfam; PF16016; VASt; 2.
DR   SMART; SM00568; GRAM; 1.
DR   PROSITE; PS51778; VAST; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1205..1223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          772..938
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   DOMAIN          985..1152
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          944..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..471
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        944..961
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1345 AA;  148871 MW;  898E2A962459E3EC CRC64;
     MSKRKVRSLS ENGLLSKLKL RQKRNKSKGS PSSSDKNNTT VSRSSLSTKK SSKNRKEVAK
     RRILSDLPAN ASSSNHIELP EIVSIKSAGR GKSTISSDGI EDTESEAELS FKPRRSLQNS
     TGGIKRKTGH HGYFNIPVTL DNQSTKSKVA SRQRSEDAST KDVAHLNIQR TPSTIDKSVG
     SPSTSIFGTI MSIAHNAVSH VPKITVNESN GLDKQFSTGS DEDSHIVANS TLSDINDANN
     DTVLHSTLPT RSASFLRHLD HLLSVSNQSP SGQFSTTSEA ETNQYSATNV SAPTMTESKV
     SIDDLASVSS QLPQSPVTKV KFQSVSTQPP AVTTLGNGNL SLDIFGNGSN VDDSSINDEA
     LSSRKNTIIS SNHHLNSLLS LQEKDHSKLS LADRIEGDDV KTKSILESKG NRTLENVLTS
     SRARSKTLPV NQKVIIKNQD DKRNSRYSSV SNDEALDMEN RANERKSRSM SKNILNRRSF
     SPTNLGLKVI PNISFRNSIS KTRNSNEQGT NIPSISFVTS NNNVSTNAAA LNNDDASRSA
     TDTILSDGLD RDIDIDDESF TELEGIEYAS EKKNAEFHNL FKDTGLGPNE KLIIDHSCAL
     SRDILLQGRM YISNQHICFY SNILGWVSTV FIPFKEIVQI EKKTTAGIFP NGIVIDTLHT
     KYIFASFISR DSTFDLITDV WNQIILGKSF KSRDNGDFQG GYSSDSDISN LSEFYDDIDN
     NDSDTEMTSS DDLDDDGFSA LPASKNSKSS AGAKFGPSKH APTEANYKLK DKEKLVSETI
     IDAPLGTVAH ILYGDDTTML YDIITAQKNF DISSLSPLIG SNTRVFTYYK PISFGFGPSK
     TKCHISETLE HYDLNEYVEV SQVSRTPDVP SGGSFSINTS TVLTWDKNNT TKVTVYFLVN
     WTAKSWIKGA IEKASYDGVI DTTKVMNNEI STFVKEKRVE WKPSKEGSVK GPAKQNHEEE
     YESTGLPTLG PAVHAPTKVP FKKEKDDVII QPGTNIAAPL GTVFQLLYGD DTSFMRKVLE
     NQDNVDISEI PKFINNERSF NYIKNLNASI GPKQTKCIVT EKIEHLDTND YIAVRNITKS
     PDVPYGNSFS VHTRTYLSWA EDNSTNMMVV SNIPWTGKSI LRGPIERGTI EGQKVANGKI
     LGQIKDVIAN SYSMKKKTTK KRQSKAKTNK VKALEVSTRQ DAEVTQASSI SPILDIIGVD
     SIKKVFAVFF SLFLLFMLYR FIFHSSRGPN VEIIRPGRVV IDGNEYNYVP NIKTLYQVYE
     DDVRKNKNSK ENLPNIVTET EDVIWDWLDN RGDGLLKHSR LFPKEETSAA NVKSRRIQQL
     IDSIQITEMQ LDEMKKMLAS IGEQS
//