ID H2B017_KAZAF Unreviewed; 964 AA.
AC H2B017;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 13-SEP-2023, entry version 49.
DE RecName: Full=EXS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=KAFR0I01870 {ECO:0000313|EMBL:CCF59967.1};
GN ORFNames=KAFR_0I01870 {ECO:0000313|EMBL:CCF59967.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF59967.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF59967.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE650829; CCF59967.1; -; Genomic_DNA.
DR RefSeq; XP_003959102.1; XM_003959053.1.
DR AlphaFoldDB; H2B017; -.
DR STRING; 1071382.H2B017; -.
DR GeneID; 13883603; -.
DR KEGG; kaf:KAFR_0I01870; -.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_006116_1_1_1; -.
DR InParanoid; H2B017; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000005220; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..368
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 672..898
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 146..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 111365 MW; 367160BB7183F6C0 CRC64;
MKFGDHLSES AIPEWKDKYI DYPNSKKKLK YIYNNHLGRP NDPVDRTFSS NSLDSNDSND
YINTTLTNHD GADLILNYSP LQLDAIKEFI ENWLIGVQLA KCNDFYIWLL NQCNKKFDTL
QSQIKVYNKQ KKILINQKFN SIPMHGYNRV DSDDENETDN NHYGSIHTES SQNDSSLAGN
TSLLTKFKDF MVSNELMPSW PKNTSSIIKQ KNKKVASDQL ENTFTNFHRP LLSSSSSIKS
NTSLTQSTIT TSNGSSPKNN SDSTKDGMQI SDNNTNNNNN NNNNNNNNNI SYFDPTKDTF
AYNAWALSDY SNVPLSKANK LLDNALLEYY LYLQLVKSFR DLNVTGFRKI IKKFDKKFKT
SELTKFLSFA QTNYSIFKHV NSNIQLITKQ MQQSSSFEPL ATSDIVPKNK SDDPLLWWEY
KIKNWYIKDL SDSNPKLMKK KSLKLKKSII KYTLNQQIIH SNNRSIGQMS WGSFALGISL
VFFIYTLGVS FKSESTSYVH KILFPIWGGV YMVLLMALLF QINCFIWHKT GINYRFIMLG
EIKSISGTRL FNNDFATTGI PLKFYALSFF LLWCAICSIN SFIWHQLNPW SILFIVGTII
LFFWPPNVIP YWDKIVETRK WIFVRVIRLI LSGLYPVEFG DFFLGDIFCS LTYSISNIAL
LSCVYSTNER GICDSSHLIS MGVFSCLPSY WRFVQCIRRF FDSGDRFPHL INGLKYILGI
AYNAALCSYR LSYHDEKRRT YFIVFATLNA MATSIWDLVI DWSLFQNSTT NWFLRDDLYL
AGKKRRKTNA KHKKYDDFEL NFDPDSYYYD TKKKLVYYFA MAFNVIIRFQ WIVYAIAPAT
IQQSAVTSYL LAFAEALRRF VWVVFRVENE HVANVHLFKV TGESPLPYPV MIRDSAIPAS
LHTGPTNFRE PSSTYHSLIR RNASVFDTIT SKIPWAHASD FQRPSTVANN LNTTESESES
ENGM
//
