ID H2B0J5_KAZAF Unreviewed; 811 AA.
AC H2B0J5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0008006|Google:ProtNLM};
GN Name=KAFR0J00770 {ECO:0000313|EMBL:CCF60145.1};
GN ORFNames=KAFR_0J00770 {ECO:0000313|EMBL:CCF60145.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF60145.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF60145.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; HE650830; CCF60145.1; -; Genomic_DNA.
DR RefSeq; XP_003959280.1; XM_003959231.1.
DR AlphaFoldDB; H2B0J5; -.
DR STRING; 1071382.H2B0J5; -.
DR GeneID; 13883795; -.
DR KEGG; kaf:KAFR_0J00770; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_004131_0_2_1; -.
DR InParanoid; H2B0J5; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000005220; Chromosome 10.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT DOMAIN 217..361
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 609..763
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 373..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 93659 MW; 46D223AAE5FA58AA CRC64;
MLRHITQDDI NLITSSQVII DLATIIKELI DNSIDAGSNS IEIILKDYGV ESIEFMDNGS
GISQENFENL TKKHYTSKIS TFDDISSLKT FGFRGEAISS IVTIAEKFVV VTNEAEGSSK
ATELDYNNDG KLTSQRVTTR NKGTTFKISK IFYNLPVRRE NFIRNIKSQF KSCINLIQSY
SIIQENISFK IFNINTKNQK KSLILSTIKS DNLFKKILNC FGLSCTKCLV PLKISLDLNS
YKSQFSKTED DFYESIDYKI ELGGYISKIN DSNSTRNLKD RQFFYLNKRP VVYPSIQKLI
TEIFKLNHIG QSNKYPMFFL NLNVNESLID INITPDKRTI MLSNEDVIMG LLKHELNKFF
QIDNDKINLS FNTSSLKRPN DEDSDLQRLS KRSTRHELTY DQEEEESATD MSSFMDKTND
YSSVSNLKSS QFNLDEYSNE HPDVKLPQSP NDNESAEIIT VNIDGEEFQH KILEEDDKLV
FLQDSDHDTS DKQILRSDNE SSDADTDHPI EINVRESFKD SPHRKEREPL NLSSFDENRR
ITEYYNTELV ADEDEIKAES RKFMNLLQDR IEKNDYDDAD RSNALNNNVE DEGYLTFSFS
KEDFNKLEVI GQFNLGFIVT LKKSSMNKYD MFIIDQHASD EKFNFEKLNK ELVLKTQKLI
VPIKLELNIV DELIVIENAD MFNKNGFKIE INDDNEPGKK VQLLSIPIYK NLTFNVEDFH
ELVDILKEKN GTSNEDDIKL CSKTYSMLAM KACRSSIMIG KPLTHKTMTR VVKNLNKLQK
PWNCPHGRPT MRHLVELNDK NCTSFTNDYK L
//
