ID H2B1B9_KAZAF Unreviewed; 1308 AA.
AC H2B1B9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=KAFR0K00640 {ECO:0000313|EMBL:CCF60419.1};
GN ORFNames=KAFR_0K00640 {ECO:0000313|EMBL:CCF60419.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF60419.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF60419.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR EMBL; HE650831; CCF60419.1; -; Genomic_DNA.
DR RefSeq; XP_003959554.1; XM_003959505.1.
DR STRING; 1071382.H2B1B9; -.
DR GeneID; 13886608; -.
DR KEGG; kaf:KAFR_0K00640; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_004883_0_0_1; -.
DR InParanoid; H2B1B9; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000005220; Chromosome 11.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220}.
FT DOMAIN 28..168
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1067..1307
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 250..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1308 AA; 149002 MW; ED501DE3AD5396E9 CRC64;
MNVFSQKNYY PVPSSEVITY RENSSATKRR SVLKSDIYAL IVFLSSPEDK IDYSVFSDFF
LIYRNFISPN DLYELLIIRF RWCINEISAE DPKRRKIGDV ALVRTFVLLR HSMLNHFIED
FLPDHHLRLS VIHFLNEDYT KYPKIITSSI VNLKKAWCQL AKLIWENLHF DEPLSSEYEK
WLSYEIKDIT TIHNRPNRLS IYAIQGASSP DFRNQSVLSL YKPDETFILP KTTPQKSDKS
RRTPTMLLFP QDNSQVPHEN NPSPDVTGSL IKQENTHKRT ISTNMGHFSK IMKNIEYPMS
PEINNIIPPT PAKKVEFILN AFYEPENSTK INELSDRENG AQVDKSPIKL NRSSSSLYKG
AVGLLAKWTK NHSGPKPSGE KHVTRSVQFP SSKTEMDTFV KYVISISALS NHNEDINEII
SSEEPKFDML SARTIDEVEY LVTLENDLFQ KINESNIHII PDIKTETNAY TENEDGALKP
NPNFSAMDNL DLYQTVNTIA HSVISLSNTL NQSSKNLYVQ NLVSPSKIKG DINSSHVSFL
TGNVTSSVVE ENKLQRTLEY NDGPQKLVFH DSTKRMSGPK DFDSDFNQTK SRFSPTYKLD
SSSPLKNVLC DLEESYANTT EDGSNSYVST RTYDSQLSSS NEAKDNSNNE YNTNNPMADP
PEESPALKKK EGFENLREFT FEDDQIVDTP EPMGSLHLDD SKLQTPVTQK ISTETAIRQS
SGRISIAKRH TATINHTATP IERIESFIAE DPDLMKKEDI LNKNERKLIK LEEILLKRTS
LTPSVATSKL FNSRPASPNK LAYEHSRVRL SMAPSMQSIV SGSSISTEIN YISPPKENNL
KERSSNNKLD KGIITTPHNY FFPTDSDDLD NASPEKDFEQ LKTKFLNTDT TDSPDVSKVA
ENRISEFHTE LNATAITDAE TTEDKINKAN LEEIANMPDE SMHDDPVTIA MMKLEGIYKK
TGMKESKSTP DLSALSKERN LLNITNESPS ASVSADKRKS LMLERRRQTI MNIPVSVENT
PQLVTPMAEE GVLPGQIQDL IKSYKLQDSR LLVANNTSHI PFILMYDSKT IAEQMTLVER
ELLTEIDWKD LLNLEIKNET LQADSWLQLL AQNETLSGID LTICRFNLIV DWIVSEIVLT
RDVKMKRNTI QRFIHVAEHC RKFQNYNTLM EIVLALNSVT VQKLVNAWRL IEPGDLLTWE
ELKKISCLDN NYATIRDLLN SVDPLVGCIP FVAVYLSDLS LNSEKKDWIE DGKIINYSKF
DTNVQVVKHF IQRVQWAKFY NFTVDHELLS KCVYISALSP EEIKELSA
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