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Database: UniProt
Entry: H2C386_9CREN
LinkDB: H2C386_9CREN
Original site: H2C386_9CREN 
ID   H2C386_9CREN            Unreviewed;      1069 AA.
AC   H2C386;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Putative protease {ECO:0000313|EMBL:EHP70707.1};
GN   ORFNames=MetMK1DRAFT_00012100 {ECO:0000313|EMBL:EHP70707.1};
OS   Metallosphaera yellowstonensis MK1.
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Metallosphaera.
OX   NCBI_TaxID=671065 {ECO:0000313|EMBL:EHP70707.1, ECO:0000313|Proteomes:UP000003980};
RN   [1] {ECO:0000313|EMBL:EHP70707.1, ECO:0000313|Proteomes:UP000003980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MK1 {ECO:0000313|EMBL:EHP70707.1,
RC   ECO:0000313|Proteomes:UP000003980};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Cheng J.-F., Goodwin L., Pitluck S., Peters L.,
RA   Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA   Kozubal M., Macur R.E., Jay Z., Inskeep W., Woyke T.;
RT   "Improved High-Quality Draft sequence of Metallosphaera yellowstonensis
RT   MK1.";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR   EMBL; JH597761; EHP70707.1; -; Genomic_DNA.
DR   RefSeq; WP_009071495.1; NZ_JH597761.1.
DR   AlphaFoldDB; H2C386; -.
DR   STRING; 671065.MetMK1DRAFT_00012100; -.
DR   eggNOG; arCOG03665; Archaea.
DR   HOGENOM; CLU_006754_0_0_2; -.
DR   OrthoDB; 56693at2157; -.
DR   Proteomes; UP000003980; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   PANTHER; PTHR14218; PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2; 1.
DR   PANTHER; PTHR14218:SF15; TRIPEPTIDYL-PEPTIDASE 1; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Hydrolase {ECO:0000313|EMBL:EHP70707.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Protease {ECO:0000313|EMBL:EHP70707.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003980};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1044..1063
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          165..510
FT                   /note="Peptidase S53"
FT                   /evidence="ECO:0000259|PROSITE:PS51695"
SQ   SEQUENCE   1069 AA;  115727 MW;  8491CFF60C219220 CRC64;
     MLKEILVITL LLSQAMPLFS PHSDYVSVLP HNQLVSVTIV ERPNNLALLQ MYVQEHKVLN
     ESQMEQLFIP RDKISSVTSY LSKFGIYTTS YLNVIEATGT VGQFERALGG EFVVIKFHDK
     TFYEYQGVTS PLVSNSLVFS SNVTQALLER PVTLYNITQA VAFSQVTPKQ LQKVYNVTPL
     LSRGVNGTNV TIGILDFYGD PYIQQQLKDF DSIYNLSNPP FFQVQSIGAY NPNDGITTGW
     ALEISLDVEY AHVLAPGAGI ILYVANPNVS LPAAIAYVDK QDRVSVLSQS FGIPEIYVAL
     GLVPLSMIQS LTYEYWLGEV EGITFVASSG DAGGNGYNFY LSPLGDLILP ASDPYVLSVG
     GTSVYYTDQG SVQSAWSGES VYGATTGGFS VIFPSPWYQG LEGQRMVPDV VADGNPFTGV
     PVLYYYNNTY LVGGTSLSSP LVSSIIALAD QIHGRLGFVN PLIYKLNGTK ALVPVTYGYN
     TPYVAEGVPN PVTGLGYINA GYFVKMITRS GGLSVAVDNT TYLDGQTVRV IVNATGQGPL
     TAFIFNGTKG EQINLVFNGT YWIGEFKASG SGVQEVVVQQ GTQEAGAYFT VGLQGLFLLP
     QVAIYPEPGN LPVLVQLTYP NGSVATSSAQ FRAVLYSYDP VTNSQKEVSS VVLSHPLTLN
     FTRYGVQISN ASNYVFGSFN FNSSMVGGIY VVRVPGVFGF DEFVGGIYVV PYVVPGVATE
     PVVVTPGQNF TLVVFAETLG SPNVTVEFVS NNRSVFNTTV NSVETNFGQF YVLEMSLPSS
     VPPGYYYLVA RASYNFTNYT ATGVGVAQIY VAPSSLRVSL LGLQETALQN STYTVNAEIT
     YSNGTPVKYG TLTAFLIPSY LQDSFDTLSI GFSVPMEYVN GTWVGNFTLP SGTTANSLGL
     SPYALSGEWQ IYLDGVSYDG IPTNTSSVLD YVTLNVVPRP LASFTLMPYV YTPFFNGTSG
     YNLYVVNARI IGHNATLVNS MVYNLTVINA TVSLVNTQVF HYSIVNGSIL NNTAITPSQI
     LTTSNEVQHT PSPTSQVQSN QSNVYVSIAI LIVGLMVALY IWVSERRKG
//
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