ID H2C386_9CREN Unreviewed; 1069 AA.
AC H2C386;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Putative protease {ECO:0000313|EMBL:EHP70707.1};
GN ORFNames=MetMK1DRAFT_00012100 {ECO:0000313|EMBL:EHP70707.1};
OS Metallosphaera yellowstonensis MK1.
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=671065 {ECO:0000313|EMBL:EHP70707.1, ECO:0000313|Proteomes:UP000003980};
RN [1] {ECO:0000313|EMBL:EHP70707.1, ECO:0000313|Proteomes:UP000003980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MK1 {ECO:0000313|EMBL:EHP70707.1,
RC ECO:0000313|Proteomes:UP000003980};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Cheng J.-F., Goodwin L., Pitluck S., Peters L.,
RA Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N.,
RA Kozubal M., Macur R.E., Jay Z., Inskeep W., Woyke T.;
RT "Improved High-Quality Draft sequence of Metallosphaera yellowstonensis
RT MK1.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR EMBL; JH597761; EHP70707.1; -; Genomic_DNA.
DR RefSeq; WP_009071495.1; NZ_JH597761.1.
DR AlphaFoldDB; H2C386; -.
DR STRING; 671065.MetMK1DRAFT_00012100; -.
DR eggNOG; arCOG03665; Archaea.
DR HOGENOM; CLU_006754_0_0_2; -.
DR OrthoDB; 56693at2157; -.
DR Proteomes; UP000003980; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04056; Peptidases_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015366; S53_propep.
DR InterPro; IPR030400; Sedolisin_dom.
DR PANTHER; PTHR14218; PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2; 1.
DR PANTHER; PTHR14218:SF15; TRIPEPTIDYL-PEPTIDASE 1; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF09286; Pro-kuma_activ; 1.
DR SMART; SM00944; Pro-kuma_activ; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51695; SEDOLISIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000313|EMBL:EHP70707.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000313|EMBL:EHP70707.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003980};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1044..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..510
FT /note="Peptidase S53"
FT /evidence="ECO:0000259|PROSITE:PS51695"
SQ SEQUENCE 1069 AA; 115727 MW; 8491CFF60C219220 CRC64;
MLKEILVITL LLSQAMPLFS PHSDYVSVLP HNQLVSVTIV ERPNNLALLQ MYVQEHKVLN
ESQMEQLFIP RDKISSVTSY LSKFGIYTTS YLNVIEATGT VGQFERALGG EFVVIKFHDK
TFYEYQGVTS PLVSNSLVFS SNVTQALLER PVTLYNITQA VAFSQVTPKQ LQKVYNVTPL
LSRGVNGTNV TIGILDFYGD PYIQQQLKDF DSIYNLSNPP FFQVQSIGAY NPNDGITTGW
ALEISLDVEY AHVLAPGAGI ILYVANPNVS LPAAIAYVDK QDRVSVLSQS FGIPEIYVAL
GLVPLSMIQS LTYEYWLGEV EGITFVASSG DAGGNGYNFY LSPLGDLILP ASDPYVLSVG
GTSVYYTDQG SVQSAWSGES VYGATTGGFS VIFPSPWYQG LEGQRMVPDV VADGNPFTGV
PVLYYYNNTY LVGGTSLSSP LVSSIIALAD QIHGRLGFVN PLIYKLNGTK ALVPVTYGYN
TPYVAEGVPN PVTGLGYINA GYFVKMITRS GGLSVAVDNT TYLDGQTVRV IVNATGQGPL
TAFIFNGTKG EQINLVFNGT YWIGEFKASG SGVQEVVVQQ GTQEAGAYFT VGLQGLFLLP
QVAIYPEPGN LPVLVQLTYP NGSVATSSAQ FRAVLYSYDP VTNSQKEVSS VVLSHPLTLN
FTRYGVQISN ASNYVFGSFN FNSSMVGGIY VVRVPGVFGF DEFVGGIYVV PYVVPGVATE
PVVVTPGQNF TLVVFAETLG SPNVTVEFVS NNRSVFNTTV NSVETNFGQF YVLEMSLPSS
VPPGYYYLVA RASYNFTNYT ATGVGVAQIY VAPSSLRVSL LGLQETALQN STYTVNAEIT
YSNGTPVKYG TLTAFLIPSY LQDSFDTLSI GFSVPMEYVN GTWVGNFTLP SGTTANSLGL
SPYALSGEWQ IYLDGVSYDG IPTNTSSVLD YVTLNVVPRP LASFTLMPYV YTPFFNGTSG
YNLYVVNARI IGHNATLVNS MVYNLTVINA TVSLVNTQVF HYSIVNGSIL NNTAITPSQI
LTTSNEVQHT PSPTSQVQSN QSNVYVSIAI LIVGLMVALY IWVSERRKG
//