ID H2CB11_9LEPT Unreviewed; 1061 AA.
AC H2CB11;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Cell division FtsK/SpoIIIE {ECO:0000313|EMBL:EHQ08606.1};
GN ORFNames=Lepil_3956 {ECO:0000313|EMBL:EHQ08606.1};
OS Leptonema illini DSM 21528.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptonema.
OX NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ08606.1, ECO:0000313|Proteomes:UP000005737};
RN [1] {ECO:0000313|EMBL:EHQ08606.1, ECO:0000313|Proteomes:UP000005737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ08606.1,
RC ECO:0000313|Proteomes:UP000005737};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The Improved High-Quality Draft genome of Leptonema illini DSM 21528.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; JH597773; EHQ08606.1; -; Genomic_DNA.
DR RefSeq; WP_002775444.1; NZ_JH597773.1.
DR AlphaFoldDB; H2CB11; -.
DR STRING; 183.GCA_002009735_02416; -.
DR HOGENOM; CLU_001981_9_7_12; -.
DR Proteomes; UP000005737; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:EHQ08606.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000005737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 732..924
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 233..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..554
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 749..756
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1061 AA; 117082 MW; 2E81C857384E4780 CRC64;
MDSASPPASP PPPPPTAGAR IAAALHARSR AVIDDLAVSK RARNVTGFIF IIAGLLSSIA
AATIDGDAAD LTGRFGIWSA HLLFALFGKA AYLFGPALIW SGLRGIARDD WQAYLSGVIG
NLSLLWSLAV FFHLSGGTEP GIAGEQFGLL LEFFTGRTGA YTINALLLFT GLLLLLQIPF
DQVKERVIDM LEGRNRTPDS DSSVWLKRAV ALVPLIPMAY SIYSKFRKSR KEQTTNAQSE
AKQSSTQETP FSGESVYGEQ NQHSAEPVGK QATSGGTPVL KRFRSEDRPP WIQKVVVSDD
GLETGSDLEE MTEEAIREAE SLSGRPHEGL EHAGMEQERP FEDRYAQIRR AGGNRWRPGH
GFDSTEDSEY NPFPDESDDA RPFSNGGDLI IEEDRFPLSS SRNDFKNDLP PSHSSRSGRH
NPRIVFDPVK NRYLFRQSAE EQALTPTRQR VELLDRMDLD LPHAYKGSFA GEKEAFDNGN
GLVATDDVAA DSYADGFVDN AGEGSQDDLL QNFDERFEPD SVDNLDETFG DAYSYAGPEE
TEDLDEEADD FTDEEPAMSA PSVAEANAPK KKADQPLLPN INMPPVVFSE NRFSRYRLSR
RIVKQTPKVE AEDPEAEIRE NWQRLEKVMS DYGIQAKVVG AIRGPMITMF EVLPEPGVRV
NRILGIQDEI RMHLAALSVR ILAPIPGKST IGVELPNRNR QYVSMGDLAN GDPEFSSGKR
ELSIALGKDI TGTNRYLDLT RLPHLLIAGA TGSGKSVFMN SVIGSLLFNH SPDEVRFLMV
DPKMVELKLF EGIPHLLYPV ITDVRLADRA LNWAVQEMES RYQLLSSAKC RDIRSYNERV
KSGALSGKLM PYIVILIDEL SDLMMVSAKE VEDSIIRLTQ KARAVGIHVI MATQRPSVDV
ITALIKANCP ARISFQVAQR TDSRVILDAN GAEALLGRGD MLYKSPTAAD PARMQSPMIS
DEEIEQLVVE ACRYGHPRFI ELPGRESDDG GGDDGGADVD QALLDSAWEI IQESGKTSTS
YVQRRLRIGY NRAATIVEKL EQMGYLGPAI GNRPREILKR H
//
