ID H2CB46_9LEPT Unreviewed; 728 AA.
AC H2CB46;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Lepil_0482 {ECO:0000313|EMBL:EHQ05186.1};
OS Leptonema illini DSM 21528.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptonema.
OX NCBI_TaxID=929563 {ECO:0000313|EMBL:EHQ05186.1, ECO:0000313|Proteomes:UP000005737};
RN [1] {ECO:0000313|EMBL:EHQ05186.1, ECO:0000313|Proteomes:UP000005737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21528 {ECO:0000313|EMBL:EHQ05186.1,
RC ECO:0000313|Proteomes:UP000005737};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B.,
RA Kyrpides N., Mavromatis K., Ivanova N., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Gronow S., Wellnitz S., Brambilla E.-M.,
RA Klenk H.-P., Eisen J.A.;
RT "The Improved High-Quality Draft genome of Leptonema illini DSM 21528.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; JH597773; EHQ05186.1; -; Genomic_DNA.
DR RefSeq; WP_002769597.1; NZ_JH597773.1.
DR AlphaFoldDB; H2CB46; -.
DR STRING; 183.GCA_002009735_00080; -.
DR HOGENOM; CLU_000445_114_62_12; -.
DR Proteomes; UP000005737; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.450.350; CHASE domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR006189; CHASE_dom.
DR InterPro; IPR042240; CHASE_sf.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR42878:SF7; BACTERIOPHYTOCHROME; 1.
DR PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF03924; CHASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM01079; CHASE; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50839; CHASE; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:EHQ05186.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005737};
KW Transferase {ECO:0000313|EMBL:EHQ05186.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 116..256
FT /note="CHASE"
FT /evidence="ECO:0000259|PROSITE:PS50839"
FT DOMAIN 511..725
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 473..504
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 728 AA; 81825 MW; B9A719244B99174A CRC64;
MSKNGQKIRF FRRPAFKEFA GPVLLFLLGA AVAFRLSQLH FENNLDRRRE AVRSDLESLR
GDLSRELLGA VHLTEGLAGL ITIEGGISEP KFRAFSRELF RRTDMIRHVA LARGSVVIYV
YPTEGNEKAV GLDYSQNEEQ WPSVQRMMKD RRLVVAGPVE LVQGGIGVIG RTPIFVTDHN
SRDPSTFWGL SSTIIDFERL LAHTSMPDIS KRLKIAMRGR DGLGAKGEVF YGEAATFGQS
PILLEVPLPD GNWQIAGLPI EGWPQFQGLF SPIFLGGALF SLLLSFFMHR LLEVNRERLH
EIRERRQAEA EMQLLRDVAI GVGVAEDMEQ ALRHVLIQIC NTTEWDFAEI WIPDSEQNHL
ICYPAWFTRR PGMEEFRKVS LPLTFAKGEG FPGRAWIDGR PIVISDLGDP DRFLRATAAV
DAGLKSGIAV PVLSGDTVQL ILCFYFAVAE ELASSRVQVV SAVAAQVGLL IGRKKAEDEV
RTLNQDLERR VAERTEELLA ANRELEAFTY TVSHDLRAPL RAINGFSNLL SESNAERLDE
KGRRYLHTIA EATRRMGQLI DDLLMFAKLN RQQIRSEPVS LDLMFDDMLE ELRIIEGFRE
VEIVRGELPA IHGDRLLIRQ AFFNLLSNAF KFTRKRADAR IVISAERQPG SVVISIADNG
TGFDMKYANR LFGIFQRLHS EDDFEGTGVG LSIVHRVVHR HGGRVWFEAT EGEGATFSVM
LPVHGEPV
//
