ID H2FUX1_OCESG Unreviewed; 369 AA.
AC H2FUX1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN OrderedLocusNames=GU3_15180 {ECO:0000313|EMBL:AEY02789.1};
OS Oceanimonas sp. (strain GK1 / IBRC-M 10197).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Oceanimonas.
OX NCBI_TaxID=511062 {ECO:0000313|EMBL:AEY02789.1, ECO:0000313|Proteomes:UP000007742};
RN [1] {ECO:0000313|EMBL:AEY02789.1, ECO:0000313|Proteomes:UP000007742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GK1 {ECO:0000313|EMBL:AEY02789.1,
RC ECO:0000313|Proteomes:UP000007742};
RX PubMed=22461556; DOI=10.1128/JB.00023-12;
RA Parsa Yeganeh L., Azarbaijani R., Sarikhan S., Mousavi H., Ramezani M.,
RA Amoozegar M.A., Shahzadeh Fazeli A., Salekdeh G.H.;
RT "Complete genome sequence of Oceanimonas sp. GK1, a halotolerant bacterium
RT from Gavkhouni Wetland in Iran.";
RL J. Bacteriol. 194:2123-2124(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; CP003171; AEY02789.1; -; Genomic_DNA.
DR AlphaFoldDB; H2FUX1; -.
DR STRING; 511062.GU3_15180; -.
DR KEGG; oce:GU3_15180; -.
DR eggNOG; COG1024; Bacteria.
DR HOGENOM; CLU_009834_22_1_6; -.
DR Proteomes; UP000007742; Chromosome.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:AEY02789.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007742}.
FT DOMAIN 13..356
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 369 AA; 40013 MW; 101983844CB8FD4F CRC64;
MNRLPTADGR HLGHLVLDRE AQLNALNLEM IEAMLLSLRE WQHDNDVVAV VLEGAGDKAF
CAGGDVVGLH RAMVTARAGC ADRELGPVPA PAARFFEREY RLDYLLHTYG KPVICVGAGI
VMGGGMGLFA GAGQRIVTER SRLAMPEVTI ALYPDVGGSW FLNRLPPGLG EFIALTGCSL
NAADSLWLGL ANRFVAEEHV AELLPRLQEE SDWPVAVGRV LRELEAESAA RLAGLDSPLR
RHQDLIGKLM DKDSLAEQVG AILEVDMHDA WFSQAQATLA AGSPLAMAVI HRQLAASRYL
SLAQVFQAEL ALSVQLCRCR EFAEGVRARL IDKDNAAHWT FAGLNEVDPA LLNTLFSSPW
GLSPLADLK
//
