ID H2J1F4_RAHAC Unreviewed; 599 AA.
AC H2J1F4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Glutathione import ATP-binding protein GsiA {ECO:0000256|ARBA:ARBA00041187};
DE EC=7.4.2.10 {ECO:0000256|ARBA:ARBA00039050};
GN OrderedLocusNames=Rahaq2_4675 {ECO:0000313|EMBL:AEX54401.1};
OS Rahnella aquatilis (strain ATCC 33071 / DSM 4594 / JCM 1683 / NBRC 105701 /
OS NCIMB 13365 / CIP 78.65).
OG Plasmid pRahaq201 {ECO:0000313|EMBL:AEX54401.1,
OG ECO:0000313|Proteomes:UP000009010}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Rahnella.
OX NCBI_TaxID=745277 {ECO:0000313|EMBL:AEX54401.1, ECO:0000313|Proteomes:UP000009010};
RN [1] {ECO:0000313|EMBL:AEX54401.1, ECO:0000313|Proteomes:UP000009010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33071 / DSM 4594 / JCM 1683 / NBRC 105701 / NCIMB 13365 /
RC CIP 78.65 {ECO:0000313|Proteomes:UP000009010};
RC PLASMID=pRahaq201 {ECO:0000313|EMBL:AEX54401.1};
RX PubMed=22582378; DOI=10.1128/JB.00380-12;
RA Martinez R.J., Bruce D., Detter C., Goodwin L.A., Han J., Han C.S.,
RA Held B., Land M.L., Mikhailova N., Nolan M., Pennacchio L., Pitluck S.,
RA Tapia R., Woyke T., Sobecky P.A.;
RT "Complete Genome Sequence of Rahnella aquatilis CIP 78.65.";
RL J. Bacteriol. 194:3020-3021(2012).
RN [2] {ECO:0000313|Proteomes:UP000009010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33071 / DSM 4594 / JCM 1683 / NBRC 105701 / NCIMB 13365 /
RC CIP 78.65 {ECO:0000313|Proteomes:UP000009010};
RC PLASMID=pRahaq201 {ECO:0000313|Proteomes:UP000009010};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Held B., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sobecky P.,
RA Martinez R., Woyke T.;
RT "Complete sequence of plasmid 1 of Rahnella aquatilis CIP 78.65.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex GsiABCD involved in
CC glutathione import. Responsible for energy coupling to the transport
CC system. {ECO:0000256|ARBA:ARBA00037530}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:29791, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; EC=7.4.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00036581};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GsiA),
CC two transmembrane proteins (GsiC and GsiD) and a solute-binding protein
CC (GsiB). {ECO:0000256|ARBA:ARBA00011469}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Glutathione
CC importer (TC 3.A.1.5.11) family. {ECO:0000256|ARBA:ARBA00038416}.
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DR EMBL; CP003245; AEX54401.1; -; Genomic_DNA.
DR RefSeq; WP_014341690.1; NZ_JMPO01000155.1.
DR AlphaFoldDB; H2J1F4; -.
DR GeneID; 61514584; -.
DR KEGG; raq:Rahaq2_4675; -.
DR PATRIC; fig|745277.3.peg.4465; -.
DR eggNOG; COG4172; Bacteria.
DR HOGENOM; CLU_000604_86_3_6; -.
DR OrthoDB; 9784450at2; -.
DR Proteomes; UP000009010; Plasmid pRahaq201.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015833; P:peptide transport; IEA:InterPro.
DR CDD; cd03257; ABC_NikE_OppD_transporters; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013563; Oligopep_ABC_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43776:SF15; GLUTATHIONE IMPORT ATP-BINDING PROTEIN GSIA; 1.
DR PANTHER; PTHR43776; TRANSPORT ATP-BINDING PROTEIN; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08352; oligo_HPY; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plasmid {ECO:0000313|EMBL:AEX54401.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009010};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 6..256
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 301..551
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 599 AA; 66121 MW; 759041CF1310BE26 CRC64;
MQTPVLQVDK LNTAFSVDGE WLNVVRDLSF SIGPKETLAL VGESGSGKSV TAMSVMRLLD
EKQTRYSGRI HFDGRELLSL TPPEMQSIRG NRIGMIFQEP MTSLNPVLKI GVQITEVLKR
HRGMDDASAR AEAVRLLEKV RIPAATSRLN EYPLSFSGGM RQRVVIAIAL ACNPRLLIAD
EPTTALDVTI QAQILALIKS LQEEEGMSVL FITHDMGVVA EVADRTLVLH RGEAVEQATT
REIFHHPKHP YTRALLSAVP RLGTMQGVAL PKRFPLTDMH TGEPLPVAES VDTLRTGQPV
LEIKNLVTRF DVKSGLLRRV SARIHAVEDV SFSLQPGETL SLVGESGCGK STTGRTILRL
TEATSGDILI RGQDIRRADS ARLADIRTQA QMIFQDPYES LNPRMRIGQA IAEPMISLGL
HDATSAKIRV AQLLEQVGLQ SNMAMRFPHQ FSGGQRQRIC IARALALEPK MIIADEAVSA
LDVSVKAQVI NLMLDLQQEL GLAYLFISHD MAVVERISHR VAVMYQGEIV EIGSRADIFE
NPQHIYTRKL LAAVPVPDPD VHHTRTVVPE ELASPLRAAT YQPPVRHYRE VSAGHFVQI
//
