ID H2J546_MARPK Unreviewed; 469 AA.
AC H2J546;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Transporter, basic amino acid/polyamine antiporter (APA) family {ECO:0000313|EMBL:AEX86063.1};
GN OrderedLocusNames=Marpi_1674 {ECO:0000313|EMBL:AEX86063.1};
OS Marinitoga piezophila (strain DSM 14283 / JCM 11233 / KA3).
OC Bacteria; Thermotogota; Thermotogae; Petrotogales; Petrotogaceae;
OC Marinitoga.
OX NCBI_TaxID=443254 {ECO:0000313|EMBL:AEX86063.1, ECO:0000313|Proteomes:UP000007161};
RN [1] {ECO:0000313|EMBL:AEX86063.1, ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RX PubMed=23045491; DOI=10.1128/JB.01430-12;
RA Lucas S., Han J., Lapidus A., Cheng J.F., Goodwin L.A., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N.C., Ivanova N., Pagani I., Vannier P.,
RA Oger P., Bartlett D.H., Noll K.M., Woyke T., Jebbar M.;
RT "Complete Genome Sequence of the Thermophilic, Piezophilic, Heterotrophic
RT Bacterium Marinitoga piezophila KA3.";
RL J. Bacteriol. 194:5974-5975(2012).
RN [2] {ECO:0000313|Proteomes:UP000007161}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14283 / JCM 11233 / KA3
RC {ECO:0000313|Proteomes:UP000007161};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Jebbar M.,
RA Vannier P., Oger P., Cario A., Bartlett D., Noll K.M., Woyke T.;
RT "Complete sequence of chromosome of Marinitoga piezophila KA3.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC family. {ECO:0000256|ARBA:ARBA00008220}.
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DR EMBL; CP003257; AEX86063.1; -; Genomic_DNA.
DR RefSeq; WP_014297134.1; NC_016751.1.
DR AlphaFoldDB; H2J546; -.
DR STRING; 443254.Marpi_1674; -.
DR KEGG; mpz:Marpi_1674; -.
DR eggNOG; COG0531; Bacteria.
DR HOGENOM; CLU_007946_1_2_0; -.
DR OrthoDB; 178667at2; -.
DR Proteomes; UP000007161; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004754; Amino_acid_antiprt.
DR NCBIfam; TIGR00905; 2A0302; 1.
DR PANTHER; PTHR42770; AMINO ACID TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR42770:SF4; ARGININE_ORNITHINE ANTIPORTER-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007161};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 469 AA; 51289 MW; C51A6498B599649A CRC64;
MSNNKVLGLF ALTMLVIGSM IGAGIFNSPA DLGSVANPGA ILIGWLITGF GVFSLAMVFQ
FLSYKRPELE GGIYSYAREQ FGEFIGFNSA WGYWWSALLG NIAFFAVIMK ILSGYFPILE
QNKIIALVFS SIILWVYHFL IVSGIRTAGT TNAILTVLKL IPLFLVAIVS IFAFNPDLVK
DIFFSTKIAA TGETASIFKQ VNDSFGTMLW AFIGIEGAVV LSNKAKSQKD VGKATIIGFI
ITLIVYISVS VFTMGVVPPG ELVNSTSPLG TVLSKVMGKP GQYILDFGFL FSVFGALLSW
LLLTAEIPYI AAVKDNVFPK KFAQQNENAT PVFSLTITNI ITQIFLLSLL SDTLQNVYNT
IFYIATTTIL LPYFFSAVFG VKVAKEENSG LYKFFAWVAV IYTAWVIYAV GWIYIITALV
IYSFGIFAYP IAKKERGEGL TGGQKLTYGV MWVISIVVIF LVATGKLSV
//
