ID H2KNG0_CLOSI Unreviewed; 643 AA.
AC H2KNG0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=FMRFamide-activated amiloride-sensitive sodium channel {ECO:0000313|EMBL:GAA36131.2};
GN ORFNames=CLF_100069 {ECO:0000313|EMBL:GAA36131.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA36131.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA36131.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA36131.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; DF142829; GAA36131.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KNG0; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:GAA36131.2};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 81..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 643 AA; 74779 MW; 30CD4A430C16E02A CRC64;
MVLKPAAMES TKEDTNEETN VLPISSEHTG VGVETKPIIQ RQCSPKSKEL CPSGEAFQLF
CKCTSVRGMS KLHTGPQFLR CIWLIFVLSM TCLLISATAL LIKDFLCYDV SVRTQLRLDD
DSPFPSLTVC HQPPFSYRAY ELWNRNDILS PAEYNRYMRK LVLDALQKND IESASSIWGY
DTLSVYYQNL DYDKVIQLGH SPSIFLSCMR SFEHTFTFED NCTILPGYML RRFSHHQYMN
CYTFEPSDMQ KAIETSFFTL VVSMGPRDRD VPPQAAFFPD IFEQARGMRI VVHEPGTMPD
LERNGIHVEP GKLNEINYEP HRWNVLSTPR RPCIQPNETH RFRDLETLFN YTHEDCLLVQ
QQLEIINNCH CIYVMYPRLS LPTKSLPYCG QIWPDYNQTA FVKRLECLAK YLDISVKRKY
DGTKCLPRCN YYMYPSTTSI TKWRGYPWQL YWLRVQNQAS ESLLKLKELH PDLNVTAQAE
FERWKLYLTY DNLTHIPSHK ELTRLGNGSD VYSEMPKWPP EKLDLDGEDF AYIVLRRKSR
NTVEENENLV LSLYVLVSRV GGLCSLTIGL TAAFVVELME FLYLFYVQRN RMKRGNEMRT
NLETTITTNN NVLEKKIVTI PLTQLTYSLE NTPENDEVCS KSD
//
