ID   H2KPM4_CLOSI            Unreviewed;       888 AA.
AC   H2KPM4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-JUN-2023, entry version 28.
DE   SubName: Full=Kyphoscoliosis peptidase {ECO:0000313|EMBL:GAA33255.2};
GN   ORFNames=CLF_102240 {ECO:0000313|EMBL:GAA33255.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA33255.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA33255.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA33255.2};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF142919; GAA33255.2; -; Genomic_DNA.
DR   AlphaFoldDB; H2KPM4; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   Gene3D; 3.10.620.30; -; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   PANTHER; PTHR47020; HILLARIN; 1.
DR   PANTHER; PTHR47020:SF1; HILLARIN; 1.
DR   Pfam; PF01841; Transglut_core; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          258..326
FT                   /note="Transglutaminase-like"
FT                   /evidence="ECO:0000259|SMART:SM00460"
FT   REGION          56..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   888 AA;  99936 MW;  99BE285F7F50E91E CRC64;
     MSNPTMRRNV DPDVIIEAFS NLMDDKGNLH SDIQQNTSWT VQTQSAFDRR GFGPQALQYG
     RVDSPGQHSG SSHPELDSGC NGNGSVQYSQ VSPPGSAISS VSTQRLPFYR QQYDQFSATA
     GGSPGYAPSG QFYRPDQSTA NWSAGPIQQE PPKEFSLLPI STETYVEKPR PQDLPSIGDK
     STAPFGSFDV FRRVDEHAVS ISQQQQDSFK QLIWQLIYAR NITDELEKVR VIFLWLCTKD
     LHKMNFDNVK PDTPEEILMG IRTGKSTYAQ IFYTLCRYAG LHCKLLIGYA KGAEYAPGMQ
     FSGRQGQHSW NAVLVDKVWR LVDCHWAARR LIGKRPSPEN VRYGLDMFYF LANPGQLIYT
     HFPHDSDWQL LRHPITLKEF ENLAPVKSAF FKYNLDLITH RNAVIVCTDP EVCVVIAFPP
     QAEKYLSFTF GLSIDNKEGS EEYRGLPLTR YGRQEISVVE HRSLFYVRPP RPGAYKLLIY
     AKHHQNGPAH QDNGAFDYSS DANSSSMYGA VCEYRLVANF HPNCSLPPYP PCQSSSYGPN
     ELAKNYQIQA KQTQCTLRAT RGCLEIRFAL GSALGLPPPR MMGRLRCTLV PDEALTRSLL
     QRSVNGNREA VFAVFLPEAG EYGLEIYANN PAKDGNSFYV VWQYIILSDS ESPVRGLPTI
     PPAYLGPMPR FDSMGLSTVS HPDPFIQANT GELCIQLNQN PDIPVRMMAQ LIHASHDVSE
     DCSQQILQQM RDNQVYFVVR FPHPGFFKFQ IYALPYSEPG ESLPGVFNYL LEATQVHRNR
     SGQVMCFPQQ FSQWKEGCYL HSPLDGILSP SAQPSDVIPF KLTVPKAIAV AVVVGDEWTH
     LNKVGDRWEG QVSLKQHWGR EHQLAVCANY NTGNGNYGTI LEYQVARR
//