ID H2KQA2_CLOSI Unreviewed; 466 AA.
AC H2KQA2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Dual specificity protein phosphatase 14 {ECO:0000313|EMBL:GAA27180.2};
GN ORFNames=CLF_103516 {ECO:0000313|EMBL:GAA27180.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA27180.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA27180.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA27180.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; DF142982; GAA27180.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KQA2; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14514; DUSP14-like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45961; IP21249P; 1.
DR PANTHER; PTHR45961:SF6; IP21249P; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 251..393
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 314..372
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 416..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 50948 MW; A5A308D373F48A79 CRC64;
MDRFSTTYSR SYRPFDEFQR NIPLRCLNGT QTSSTLLNGS RSPGVARLAR CWPSDLPASQ
TTSFASSVGD TCSSTSTYAI YQPPFTRSAN DNDSPGFPLS WDVSKPIIDK QRPTPPSMCA
SSTTANRLGF SFDDTVTSGL SSISTCATNK DCASSSSTVI SADKLNACHG LSNGVTEDLT
FATKTPLLFC APQARTLPTI SNTVGCNSDI GSDLTHGNCR KIPVTTERAV TVNPTSPPPG
SQLDFTQMYS QVARINNHLY LSSLNALTPD RLRQYGITLL VSAMVDPPPA QLRNAVISSM
HVAVEDMEGA NLRAHFDRVG DRIASEQRRG GRTLVHCMAG VSRSSSLVLA YLMRHMNMTL
ADAYQHVRSI RPCIQPNPSF WRQLLEYEER IHGRRSVRLL PPVGYMGSCG ISPTSRLYSG
DRPSPRTSHL DMYSRPTSDL LPYRPITSMH SLDSGKPYVG CRQPLG
//
