GenomeNet

Database: UniProt
Entry: H2KR43_CLOSI
LinkDB: H2KR43_CLOSI
Original site: H2KR43_CLOSI 
ID   H2KR43_CLOSI            Unreviewed;       647 AA.
AC   H2KR43;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   08-NOV-2023, entry version 45.
DE   SubName: Full=FMRFamide-activated amiloride-sensitive sodium channel {ECO:0000313|EMBL:GAA38650.1};
GN   ORFNames=CLF_105403 {ECO:0000313|EMBL:GAA38650.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA38650.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA38650.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA38650.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DF143103; GAA38650.1; -; Genomic_DNA.
DR   AlphaFoldDB; H2KR43; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; PICKPOCKET 17, ISOFORM A; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:GAA38650.1};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        558..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  74362 MW;  937464D856562512 CRC64;
     MDNHQLVTVS SNENKETESK GITTNNTALD SSQPDDSSSL PTDPMNCNYP EVASTIPAPR
     KPRTFGEISS IRGVQNISRA ETPFIRSLWI LFVITMTSLL TIFSSFLIRD YLLYETNWHT
     RTLRDDKTAF PSITLCAHNP FSLEANRFWR EGSTPNPKQI NSRFTEIATE VLRQHNVAFS
     INLLLLDSIE TFYTNLDPKV RYNIGHKMEM FPHCMVTSES AHIVAEKCKL ELDTELHLHR
     ISHPKYFNCW TIEGKALEAT KEITRLIMLV QLVPSKKINE ANLSFIMDTF TRGEGVISVV
     HEPGTYPEIE KHGINIQPNR MNQIIYKPVL WNRLATPKAP CSEHPPPISD LGVNYTYTQG
     QCLNTVLQEQ LLARCGCLNT EYPRPASTDF PVNPTPYCTS LNESLTNPEM ASKLIERFQC
     IGEVMDRLKE IKEEAARQGR CPPRCSYFTY ENRLSVTLWD PNAHNLAAYT ERYRKLDGLL
     KAQSSMNMKT SFVSYWNASI QQFSSLDLDS HNQPERFAEY SQFVDGSVTY ISLTRQEFET
     TVMDERLVFD VYILISRIGG LCSLCIGLTM AFFIEVVEYA YMRLLYNRMS EQSRKWGFRR
     PAHVTQTNVP STELSNIDGS RTVLRRTRRK RYRMCCCHRQ WPKSPSV
//
DBGET integrated database retrieval system