ID H2KR43_CLOSI Unreviewed; 647 AA.
AC H2KR43;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 08-NOV-2023, entry version 45.
DE SubName: Full=FMRFamide-activated amiloride-sensitive sodium channel {ECO:0000313|EMBL:GAA38650.1};
GN ORFNames=CLF_105403 {ECO:0000313|EMBL:GAA38650.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA38650.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA38650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA38650.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; DF143103; GAA38650.1; -; Genomic_DNA.
DR AlphaFoldDB; H2KR43; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF248; PICKPOCKET 17, ISOFORM A; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:GAA38650.1};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 647 AA; 74362 MW; 937464D856562512 CRC64;
MDNHQLVTVS SNENKETESK GITTNNTALD SSQPDDSSSL PTDPMNCNYP EVASTIPAPR
KPRTFGEISS IRGVQNISRA ETPFIRSLWI LFVITMTSLL TIFSSFLIRD YLLYETNWHT
RTLRDDKTAF PSITLCAHNP FSLEANRFWR EGSTPNPKQI NSRFTEIATE VLRQHNVAFS
INLLLLDSIE TFYTNLDPKV RYNIGHKMEM FPHCMVTSES AHIVAEKCKL ELDTELHLHR
ISHPKYFNCW TIEGKALEAT KEITRLIMLV QLVPSKKINE ANLSFIMDTF TRGEGVISVV
HEPGTYPEIE KHGINIQPNR MNQIIYKPVL WNRLATPKAP CSEHPPPISD LGVNYTYTQG
QCLNTVLQEQ LLARCGCLNT EYPRPASTDF PVNPTPYCTS LNESLTNPEM ASKLIERFQC
IGEVMDRLKE IKEEAARQGR CPPRCSYFTY ENRLSVTLWD PNAHNLAAYT ERYRKLDGLL
KAQSSMNMKT SFVSYWNASI QQFSSLDLDS HNQPERFAEY SQFVDGSVTY ISLTRQEFET
TVMDERLVFD VYILISRIGG LCSLCIGLTM AFFIEVVEYA YMRLLYNRMS EQSRKWGFRR
PAHVTQTNVP STELSNIDGS RTVLRRTRRK RYRMCCCHRQ WPKSPSV
//