ID H2KR57_CLOSI Unreviewed; 1119 AA.
AC H2KR57;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=CLF_105540 {ECO:0000313|EMBL:GAA35712.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA35712.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA35712.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA35712.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DF143110; GAA35712.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KR57; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF12; ADENYLATE CYCLASE TYPE 3; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 798..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 317..444
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 932..1072
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1119 AA; 128074 MW; 60A0510136E9059B CRC64;
MQRHLGWLAR SRAFHLSLRR TLVQPSASYT LVDKLGQIYR DISSILSFHS KVYENYFNAA
SIQYTRRCFR SALIFPFITY WGCVFATAYN TGGFEEHGIN LFLALMVAAL LLYLLSYNKY
SHQWYSRTSC AVLAVAFSIS MIGSMEVIVR WISIIPYLEM LFSLCIILPL TLDFTLSLIV
LFSFAYMNTA EHQITFTTCG NETYSHRTNL PDVHLRTPIS YCGNRPGVTI EFVLCILIFI
IGMYLQFWNT IRRRAAFIYI GQAVHLQRRN RKVLATNENL RDVLMPSFIW HKYEGKENLR
QTYANRRLYL QAAVDVTILV TELVNFRELI STQDIQTVVL IMSDMIDYFD RKSDEHDCER
LAVLPDTYVY TCGVVKSRMN HARSCVELAR AMVHVNEHLT LERSHLVLLR VGVHTGKVAI
MVWGGRKIHY DLISPDVFIA FHVKDSGPPG YITISDDTHT RVHMNFPTEL GERLILQTEC
LVDGKFTVRS KALQTYYVTQ EPTKMESSST SSIKSEPGLF ERCVQLMGQI RASKSRKPTL
LNQDFASEAF AVATTVGSRS VFSISPKELV TPSTSIHCSG EISRWNKDRT EGLDSSKPYQ
LDAEVLRLIT QLRADPKRQI TLMQYIPVGT WSNVFTNREL EWHYVNHVQD PNNPIYIDSL
KLAPAMDAIM ILVTTVILMV CSVIFTGYKR SDSRIFILYA LEAFVALLLC VCICWTSTRF
VQSVTTGAGR RLFVIMSKNS TRQFFVFVLT ILPSIHSFIF FSLFEGNAAR ELRSNNALIV
FNTISSLNIM VATTNPKWIG VLSLFICHFG YLYICGAITD QTPFSSSTWD SINGLVRAED
LLSDELIRIC TSLVVVLTMI NLNERNCRLN FIAMRELQIS REESEIYHTK LREMMDHLLP
SYVTRELLRS RSSIPHSSVK HHNAEWENVG VAVLYISNLY ITHWNLESQQ RELSLKVLNL
FVCTIDDMIS SGKFSELEKV RFFNDMIVLA SGLNHFKNWD CSDTTHMDIL VEFCVQAQRR
MQRINSEHLS KKRLIDLKIG YTRGQVTTAV IGLQKPTFVV WGRSVEVAEN IARNAFAQEV
QTVFECTLIL SAQYEAILAG VIPVENEGLL DTYIVRPHR
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