ID H2KRL5_CLOSI Unreviewed; 1763 AA.
AC H2KRL5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Histone-lysine N-methyltransferase MLL3 {ECO:0000313|EMBL:GAA32467.2};
DE Flags: Fragment;
GN ORFNames=CLF_106624 {ECO:0000313|EMBL:GAA32467.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA32467.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA32467.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA32467.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DF143187; GAA32467.2; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0043933; P:protein-containing complex organization; IEA:UniProt.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:GAA32467.2};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:GAA32467.2};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1243..1351
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 1623..1739
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1747..1763
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 114..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GAA32467.2"
SQ SEQUENCE 1763 AA; 192783 MW; FE38B13AABBCF72E CRC64;
SAFRLPQQRA RCGMELSGMS KVSESTLISS SASCQTHLYD RIPRSPTAVV QPSSPIPSAH
NSAGTDGLKF TLVDESPCLA AFKSQTDNNH HSISPEISFA TFSNNLERTD DLSVTNQATS
GPDLSQFPND DSSDINRSSN VGKSHSTPLI CTSPAAAPGS TFFSPDHQLL NGGSTPISFV
CPADCTTPTA ADTSLDVNGL SGSHTTASPN DVDRTRMDLT KLDETIDYVL SAARSDDPCE
GLFVLPCRTR EHTTLSSPTL RANTPTSGHL FSPSPSPTPS SPQSCHATAS PLNSTNKQLH
LYVSSSSVSS IATATSMPRY VVDQSSGLVQ LSTGVVNSQC LPAMCNGQQS LSFVQVFSDP
PSSSRIPNHE RSTVPQLGSL VTSPQVVFHS GLSHAVQNHS IAQVNHTLLP TAAAVRGCGP
LVSPNKSNLL SPATGSRSTK LSTIPCAPFS SIDPLLSPNR AVVISPPMCV VQNPRLASPT
RNVPVFSTSS NDMPNQCPQL PGERRHYVHS QVPVSFRQPI VPAQTFTPSC ISAANTVCLQ
PTVPDQNIPL VHPGPTTAES LRHITQNHSA ASRKRSNTSG SGLSKRRKTT AAPPTSLANG
STNLIKGSLI EPNSPYRANI VAHEYFEKLK LGDLKSLVSA PVLRPYPSVL PPVGGSDIVT
PFLKVDDEQS VLCRKGLKYI HGSMSVHIPK CSLSEASDRK VDSYILRHLP NATFTGPLVC
GSKNPTHAMS PTSPVCPSPE PLTFENHMLA LFSTFNRSPK EECKSTLVVD RSVSQNTSNM
PSFASRLLPM LTEVTPNSGK PDPERSTPPL PLFHMPNPRL VYDHARSGST DRDGVEFNTT
AQSETSRSNS TFIYNSPSRE PNDVKPPVIT APGTGPLIDS ETGEIVAGHR FRPPAESMHS
DKLHITFTIN PSMTGGIPKI VQRIAELLGV EQDSVSYQVT RSGAQITLDQ KQSQSEGLMR
NLESQLREHF TPLSLHVETA SVRPTDSNIH SDLQTVVERE ELSNHPGTAR PELKQNVDTS
NLLKLDGPCI TNSEWARYSE EPVSVVSLLA NKNGVSKPCQ NCDTLVSPYS GHRKTLDDIA
ALTGLTTRTD TNGDFIFCSK DCMLAFAHSI SVRRLSLESP IACPTSATTT GSVSDSRPQT
LVCDLFSTVP VVLQSSLPKL GKSSRRHLTG VHIVASGHKR RQVSAVHGTA KHRRWRDSRW
RIFSPEFVPT TTPAPSDKLI TSGPITFSRD DGPCLRPPPS ADPRRCTLCG TKGDASENGL
GRLLPMNIDK WLHVNCALWC YEVYETVGGS LNDVDIWIKK AMETNCTHCG HLGAGLPCYN
PRCTFSYHVS CAIAIGCMFF TDRGMYCPQH QPRETHPMQL PSLLVNRRVY ITRDENAEVG
GVIHEEDRTK IVRIGSVCLH NVGQLLPHQI ESGYFHTRRY IYPVGFHTTR IYWSMRRPHR
RARYVCEIDE ADGRPSFRIT ALDDGLEDVT VVSDSCTGAW QVILSRIEGM RRENHMVQLF
PKHIKGEELY GLSEPHIVRA VESLPGMDGL RDYVFNFGRM ELIAEMPLAI NPSGCARTEP
KMQTYVKRSF LSSHKLTPTT SSPVGFRRSV HPSLSISTPS DYSKQYQSSR SQQYRRLKGE
ASSNVILGRS RIQGLGLFAA RNLEPQTMVI EYIGELIRLE LANKREKDYE AHNRGIYMFR
LNDDTVIDAT VCGGLARYIN HSCQPNCFAE FLNFGDHSHI VIITNRLIEK GEELCYDYNF
DLEDGGSKIP CLCRSTNCRK WMN
//