ID H2KRU7_CLOSI Unreviewed; 696 AA.
AC H2KRU7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=CLF_107202 {ECO:0000313|EMBL:GAA27790.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA27790.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA27790.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA27790.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; DF143228; GAA27790.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KRU7; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 623..694
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 696 AA; 79194 MW; 8839354B5BBA5D3F CRC64;
MLCHNDNSHK DTFERFSQYL SSDPYQTSKC EEVRALLEYI RSQSSIMTGI GNFDPWLVNL
IDTDDFSQFY ARYIRLLYTK SPTDCISQPA NQFVYNFIEL QVVVWNLTDK TDSLCLRLIN
KDVHGELFRL IGLSQFDPSH CLEERNARLI VHSSIGILHN LVRSVPTIRS WYRQANGTQI
LSRFLSYADW NKDCIEQPLL QYFSVLTAVL LLLSFLVSES ENDVLLANDK YFVYLSKVLE
DALDSTTLQS CKYGYGANEL FAGLQNLAGS DENKKALIKN GAFSYIKKAL NMGYHSRYHG
QQEQSFSMPT MDLQVHDLTG NALELLWCLS FVPDCVDHLV PGSELRRMID QISEGKNWPA
DWRKAASGIC WNLNRSRATP SVNPIQVDAM MATERLQSRR GKHLMISYKH STQRIMLKVR
DELRCRGYIV WMDVENMYGS FVDAMAKGIE QAAGVILGIS QEFKNSPHCR QEVKYAYSLG
IPLFPLTLEP DFFADGWLGI LLAALPRISL TDESMVPDAV AHLAKQLGVR GHVSEFNSRS
ETQFSRKLDE RSAILSLFEK STQSFSGHHN EQINLPSSID FMSDAPRIAL HQPITTHHPG
QECEKPVISS HSLMPQMANV YFWSELEVCE WLDKANLSSY REAFSNVNGQ MLVELARLRL
VALDALCEGL FRNLGMKLTD QLRLLAALHQ LSSTKL
//