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Database: UniProt
Entry: H2KRU7_CLOSI
LinkDB: H2KRU7_CLOSI
Original site: H2KRU7_CLOSI 
ID   H2KRU7_CLOSI            Unreviewed;       696 AA.
AC   H2KRU7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN   ORFNames=CLF_107202 {ECO:0000313|EMBL:GAA27790.2};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA27790.2, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA27790.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA27790.2};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC   -!- SIMILARITY: Belongs to the SARM1 family.
CC       {ECO:0000256|ARBA:ARBA00008291}.
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DR   EMBL; DF143228; GAA27790.2; -; Genomic_DNA.
DR   AlphaFoldDB; H2KRU7; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR   PANTHER; PTHR46270:SF2; TIR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          623..694
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
SQ   SEQUENCE   696 AA;  79194 MW;  8839354B5BBA5D3F CRC64;
     MLCHNDNSHK DTFERFSQYL SSDPYQTSKC EEVRALLEYI RSQSSIMTGI GNFDPWLVNL
     IDTDDFSQFY ARYIRLLYTK SPTDCISQPA NQFVYNFIEL QVVVWNLTDK TDSLCLRLIN
     KDVHGELFRL IGLSQFDPSH CLEERNARLI VHSSIGILHN LVRSVPTIRS WYRQANGTQI
     LSRFLSYADW NKDCIEQPLL QYFSVLTAVL LLLSFLVSES ENDVLLANDK YFVYLSKVLE
     DALDSTTLQS CKYGYGANEL FAGLQNLAGS DENKKALIKN GAFSYIKKAL NMGYHSRYHG
     QQEQSFSMPT MDLQVHDLTG NALELLWCLS FVPDCVDHLV PGSELRRMID QISEGKNWPA
     DWRKAASGIC WNLNRSRATP SVNPIQVDAM MATERLQSRR GKHLMISYKH STQRIMLKVR
     DELRCRGYIV WMDVENMYGS FVDAMAKGIE QAAGVILGIS QEFKNSPHCR QEVKYAYSLG
     IPLFPLTLEP DFFADGWLGI LLAALPRISL TDESMVPDAV AHLAKQLGVR GHVSEFNSRS
     ETQFSRKLDE RSAILSLFEK STQSFSGHHN EQINLPSSID FMSDAPRIAL HQPITTHHPG
     QECEKPVISS HSLMPQMANV YFWSELEVCE WLDKANLSSY REAFSNVNGQ MLVELARLRL
     VALDALCEGL FRNLGMKLTD QLRLLAALHQ LSSTKL
//
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