ID H2KSV2_CLOSI Unreviewed; 748 AA.
AC H2KSV2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Nuclear receptor subfamily 2 group F member 1-B {ECO:0000313|EMBL:GAA34732.2};
GN ORFNames=CLF_110418 {ECO:0000313|EMBL:GAA34732.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA34732.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA34732.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA34732.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF143517; GAA34732.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KSV2; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06916; NR_DBD_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR PANTHER; PTHR48092:SF9; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:GAA34732.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 217..292
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..170
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82271 MW; 1DEC9E984D415DC3 CRC64;
MYPIPGAHAP HYQHTPDYQQ NSGPYHALLG TSSPTWRDRL PIAQDPIVQY RELDLLTRQG
VLPVAHNDET ANSSVSSNHG SQDHTSRHHA PQLPARLMTV PDLDCASQLS STHSPPKGSM
CSTRSNFSVA SDGETNSSDA SKSQIKRDED SGEHESAEET TSEEEGEEEA ESEEVHLCQM
LCGVFDRPFT IAHQVHISRL FVEFCAYGFV RFGEYVDQQA RVCGDRSSGK HYGQFTCEGC
KSFFKRSVRK SASYVCRSEG QCPVDAQRRN QCQACRMTRC LLAGMKKEGL RSTVTLGTEE
SDLSSFSLIA KTLDSVSRSL VTNESSKSGE SGLMTSYFFP LESVQRARIS TMLQASFPPN
YTTAHSSANQ TSGFTAMRYD RNALFYANNL ANRQHYSATD YNPLSSYTHA TPETPINLDA
SRFSSAALAA AARRFTSAAA FSTAVGQDTG YLIGHRTLPH TLESSTSRLP PPNSLVHMHP
NVYHSEGNLH LSSISALTKL PPAGTQQAYP YPWDSRAPQV NYQGTSISSR PYQLTPPPQI
FWNPSASVPD GSATHNPCPK LKPPSGSPSP STTNKQPSFG PDSSCPGQIP ATSEPGRVYL
GPLDVIREWL QRLQFPSGAE PQSDLAACER SALQALQPIN TLIKRLYADR QEWKRHRFAH
WSQDDEEDGE CEDVGLNEQW LLASSYEDQF PGSTCSSAVA QSPDTTQMIS VELDELDRQK
LARHGSVTLS ILAEIEVGYQ FLIPVNAL
//
