ID H2KT67_CLOSI Unreviewed; 812 AA.
AC H2KT67;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 28-JUN-2023, entry version 32.
DE SubName: Full=GRAM domain-containing protein 1B {ECO:0000313|EMBL:GAA29960.2};
GN ORFNames=CLF_112093 {ECO:0000313|EMBL:GAA29960.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA29960.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA29960.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA29960.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; DF143709; GAA29960.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KT67; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0044232; C:organelle membrane contact site; IEA:UniProt.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 687..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 393..578
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 208..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 90247 MW; 4067856F66FEAEA3 CRC64;
MPPGPTKAQR SGRIKRRSAR HDMRMVTVRT LDRLYPFYFT DDLAECMRKG YLTAKEAQSL
APSYKSKLEQ FRRVFRGTPV DTERLLVDYS CALSKNNHGL LQQGRMYITE NWVCFYSKII
SEQKIYLAVK EIIAITKEKT ARVIPNAIQI IYSKNHQRFF FTSFSSRERT HAILRKVWEN
CRNNQSMSID EIVQQVREIY GDDSLAMLED EDTDGDPDTR ENPFPSRIRT TSDSSDPNLT
SADTANNANV DATMWGSDNG ANQSGGLSGF ATTDEEGFNE DGLHRDRVLD FDVQVLPSSM
EVGIRRRCHT PDLRHNAADS AATETDPALH ETHSAGQLSM KSERKRRSKK RPSRTQPSSG
IPPSQLTQFT LSPSVSAEGP DSVVTCFPGH DHPGQLYADA LIPLNVDALF TCIFTDSVFF
DRLSTARGTF NLAQSSWPTV NWSKSERDMS ATEPIVNPER TIGYTLKLNQ KLGPRTCAAI
EQQTLLVSES QPGRCYVVDA KVTNQAVPLC NCFCVVSRYC LLRIDRTNSR LRVSSRVVYE
KPVFFGAKSI IENTCRSGLT DFFTALVTHL TEMASALTEE ERLTGACLSA QSTNSAVIHD
GVRSRNPAKI VAQRSQLNGE LGDINPVDVA RKRGRSDAKS PTSPASSPSH RRQFKSSANP
PSNAPVFIAQ SASLTEIGYF FLRPDRAWLL LVVVSLLLCL CLSMVYNRLV ALEHLAEQLS
EAQSPTKFVG PGFMDQLASS FTRNPTSFDA SQSRLRVMKE LTISMSQTLT QIQNVLSQVH
HTIELLDSSR TGPTTSPSSS NSDTGPSAHD SS
//
