ID H2KTE3_CLOSI Unreviewed; 971 AA.
AC H2KTE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 28-JUN-2023, entry version 44.
DE SubName: Full=Rap guanine nucleotide exchange factor (GEF) 4 {ECO:0000313|EMBL:GAA33055.2};
GN ORFNames=CLF_102676 {ECO:0000313|EMBL:GAA33055.2};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA33055.2, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA33055.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA33055.2};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
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DR EMBL; DF143888; GAA33055.2; -; Genomic_DNA.
DR AlphaFoldDB; H2KTE3; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 410..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..246
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 700..936
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 473..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 110795 MW; C3E4F89FD42B6864 CRC64;
MLASGVWQAL LEESAIQPFD VMGTRKVADV PEFMDSPQEM YRCTCPLDVS LSLEEDLEAV
STNTLRKQEK PADFLGRKSM FSRSHTLSTD ADDAVTAEDR FQLLIERLYC LASAALLRRI
LAKSPNQRTG VEVEFVSQEL LMVPALANFP NSVRNELSKC IKYEVHPLSN KLVFRQGDPG
VCWYIIYKGS VWVHIKSQGY VCRLYDGDDF GKLALVTGDP RAASIVLAEN NCHFLRVDKT
DYDRVLVDVE ANIVRLREGD SDVLVLECVK FTCRESASSV HGFEQTATTE PENKRLTRAN
NQLIIAGTID KILRHILDAR LSIYDDQLPN LVSRLEKLYR LCPFPQVEID IVVEEFILTL
TMFTTNSDVF NLLFAYLSQD RSNGAGKADQ LTSTQNENPE VYQDCFSRRV LILLYLWCMC
IGLLAFASLD GLRKFLSDIK QLISCRTNCD LEKKAVEVLL KECDQIWNPT HHDARSTTEH
DSLKKNNSRK KPSQKCGVLS GTRALFTRGK QIVKSLPCAL QQLSHYTHHV QRSMYYTPYH
LNRLRIEPHS LPFTPRTHTI TFLVYLGEDH RKVILTLPVD TTVQRIKSRL SSELPSGAEI
NDYEFVEVRS TGERITYTDG ERGILFSLSP NSCLFFVPRQ DRAKLVPLPI QLNVAMSFLD
QTDPGRSMTE IQRKESSLSS PKMKKSISVS QHFSALEELS VDEIASVFTF SHIQLAMCIT
ASELLNYTMG SEKSGCATPH IRLLVAQFSL IHAWTITQLV TTPVLNKRVQ FLKRLIKLAD
RLISSPFHDQ HTCFAIVMAL QSAPISRLTQ TWDRLPVRWK RLYQNRLLPL IDPARNHRAA
RNWIAENIQN CLPFLAILLK DLRFAEDGNS TIYAQQQPSK VRLINFEKMR LIARTLHVWN
MAISGYEELH PFAKRMHCPP RELTATGELQ FIPQTLQSIS SEVLELFYDH MDCIDDLQLL
SQLAWRIEPK K
//
