ID H2KYA1_CAEEL Unreviewed; 523 AA.
AC H2KYA1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=LIM zinc-binding domain-containing protein {ECO:0000313|EMBL:CCD62013.1};
GN Name=prkl-1 {ECO:0000313|EMBL:CCD62013.1,
GN ECO:0000313|WormBase:ZK381.5a};
GN ORFNames=CELE_ZK381.5 {ECO:0000313|EMBL:CCD62013.1}, ZK381.5
GN {ECO:0000313|WormBase:ZK381.5a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD62013.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD62013.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD62013.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CCD62013.1; -; Genomic_DNA.
DR RefSeq; NP_741435.2; NM_171372.2.
DR AlphaFoldDB; H2KYA1; -.
DR SMR; H2KYA1; -.
DR IntAct; H2KYA1; 18.
DR STRING; 6239.ZK381.5a.1; -.
DR EPD; H2KYA1; -.
DR PaxDb; 6239-ZK381-5a; -.
DR EnsemblMetazoa; ZK381.5a.1; ZK381.5a.1; WBGene00022727.
DR GeneID; 177463; -.
DR KEGG; cel:CELE_ZK381.5; -.
DR AGR; WB:WBGene00022727; -.
DR WormBase; ZK381.5a; CE41743; WBGene00022727; prkl-1.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00940000153629; -.
DR HOGENOM; CLU_025413_0_0_1; -.
DR InParanoid; H2KYA1; -.
DR OMA; CDEVIFG; -.
DR OrthoDB; 370973at2759; -.
DR PhylomeDB; H2KYA1; -.
DR Reactome; R-CEL-4608870; Asymmetric localization of PCP proteins.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00022727; Expressed in pharyngeal muscle cell (C elegans) and 7 other cell types or tissues.
DR ExpressionAtlas; H2KYA1; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09340; LIM1_Testin_like; 1.
DR CDD; cd09341; LIM2_Testin_like; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR047120; Pk/Esn/Tes.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24211:SF20; PROTEIN ESPINAS-RELATED; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 4: Predicted;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 40..148
FT /note="PET"
FT /evidence="ECO:0000259|PROSITE:PS51303"
FT DOMAIN 147..210
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 211..270
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 378..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..410
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 58834 MW; C232F3DE7B7916C4 CRC64;
MSERIRRRRL EASEQFAPQL ISSRRAQGGL SPASRIRIAA DAHRHSTSDD DSGCALDEYA
WVPSGLKPNM VHAYFACLPE NKVPFIGSAG EKWRQRQSRY QLPPQDSDVR YCEDLNAEEA
DTLRMFERTR KTECLGSGVV QYAPFDTKCE KCPKRLEEGE ISVMAARTGK RYHPSCFRCQ
TCDVLLVDLI YFAHDNQIYC GRHHAEQVKP RCAKCDEVIF GDECLEAEGR SWHFHHFQCA
QCNDVLADQK YMQRANKPVC LKCFHSSSST FSCTTCRLSF SSDTPHMSQG DLHWHASAEC
FCCCVCSKNL LGVKYSRVGE SLFCGYQTCG GEDEELLDED RLGSPHRKVT QKSTKVVRIP
ASPRVAPRHP HVIQQNLTTT MTIQKPSVVI QNQRPKPPQR APPPPPSENI YETVLPCSSN
NSPNFDKKYS HELPTSPNHH NYYSKTPNNL LTGYPEMDGY STSSSSDSDD EQLYISNIMA
AASLSRVPAK SSSRKSKKNE PMMMSGGGVR MAKKKKSSRC TVS
//
