ID H2KZ99_CAEEL Unreviewed; 514 AA.
AC H2KZ99;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000313|EMBL:CCD67137.1};
GN Name=gnrr-4 {ECO:0000313|EMBL:CCD67137.1,
GN ECO:0000313|WormBase:C41G11.4b};
GN ORFNames=C41G11.4 {ECO:0000313|WormBase:C41G11.4b}, CELE_C41G11.4
GN {ECO:0000313|EMBL:CCD67137.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD67137.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD67137.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD67137.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284606; CCD67137.1; -; Genomic_DNA.
DR RefSeq; NP_741799.1; NM_171954.4.
DR AlphaFoldDB; H2KZ99; -.
DR EnsemblMetazoa; C41G11.4b.1; C41G11.4b.1; WBGene00016570.
DR GeneID; 180841; -.
DR AGR; WB:WBGene00016570; -.
DR WormBase; C41G11.4b; CE30896; WBGene00016570; gnrr-4.
DR InParanoid; H2KZ99; -.
DR OrthoDB; 4815971at2759; -.
DR Reactome; R-CEL-373076; Class A/1 (Rhodopsin-like receptors).
DR Reactome; R-CEL-391906; Leukotriene receptors.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-417957; P2Y receptors.
DR Reactome; R-CEL-418555; G alpha (s) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR Reactome; R-CEL-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00016570; Expressed in larva and 2 other cell types or tissues.
DR ExpressionAtlas; H2KZ99; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24232; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24232:SF53; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CCD67137.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..514
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 514 AA; 58997 MW; 0FA7DB40E986B4A4 CRC64;
MSEATQQETQ RVELSFSYTL ELWMYGIAFC VGLPAFIFTV VRLARSRSSR QHLVLAARLF
SYKISLSVAD CIVLFIYAPT QFAWIHSYWW FGGDIGCRLF KFISTFGFHL TANMQVLVAA
DRLLITAKMN RVTRNIKKRQ YNTRLSLAAA WILALICAGP QLILFRQKTT PQGYPQCISI
WTEHRVDFYD RLELLEQYAY MQHELANKSP IYFFENGTLR YAKEDFPSEP GFTLEELHTN
NRNWLYLERL YNVLHLATIC VIPYAMELIC YTLILYILKG ASKGRFVSLS DIVKDIFCCC
KRARQHESPI ESNVTQESDN LMARVPSKTK RLQNIAPEGK SCDMERRRAA SVDVPMRIKN
SSSLTVCIDE NGSATAATRP EVTPQEQEPE TRTQAFKRRV WNFLLDLFHN GSEGSVHFNG
HKTELRLPNL TKGEARRQSA PASARSNTLW VVTVDTARRN ARWKAFIMLS LNLVFWAPYC
ILAITSSVII SQYLTNFQFV NALVTFNAVS NIIL
//
