ID H2KZE8_CAEEL Unreviewed; 477 AA.
AC H2KZE8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|EMBL:CCD67912.1};
GN Name=kvs-1 {ECO:0000313|EMBL:CCD67912.1,
GN ECO:0000313|WormBase:C53C9.3c};
GN ORFNames=C53C9.3 {ECO:0000313|WormBase:C53C9.3c}, CELE_C53C9.3
GN {ECO:0000313|EMBL:CCD67912.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD67912.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD67912.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD67912.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284606; CCD67912.1; -; Genomic_DNA.
DR RefSeq; NP_001024491.1; NM_001029320.1.
DR AlphaFoldDB; H2KZE8; -.
DR SMR; H2KZE8; -.
DR EnsemblMetazoa; C53C9.3c.1; C53C9.3c.1; WBGene00002242.
DR AGR; WB:WBGene00002242; -.
DR WormBase; C53C9.3c; CE36283; WBGene00002242; kvs-1.
DR HOGENOM; CLU_011722_4_1_1; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00002242; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; H2KZE8; baseline and differential.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IDA:WormBase.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IDA:WormBase.
DR GO; GO:0043056; P:forward locomotion; IMP:WormBase.
DR GO; GO:0006972; P:hyperosmotic response; IMP:WormBase.
DR GO; GO:0007638; P:mechanosensory behavior; IMP:WormBase.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; IDA:WormBase.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR GO; GO:0050920; P:regulation of chemotaxis; IMP:WormBase.
DR CDD; cd18317; BTB_POZ_Kv; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF262; PROTEIN CBR-KVS-1; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 214..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 73..172
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 219..468
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 477 AA; 53428 MW; 336CCDCF6D610C22 CRC64;
MSTERLMYLD LNKGNQIAMV IPSTRKGHAA SRDNFGNSNH HGDEIVHRLN NGRRSEIDEV
KPDLVSGAGD TVIKLNVGGT SFRIRISSIF ARSADEKLSA FAQLNHEQRL QACDAFLMPQ
EEYYLERSAV LFDSIFKYYI SGQLHRPLDV CPTEFATELA YWKINDGLMS NCCWRGYNMS
PSLEELVAPK EKKIELHDRS MRSRIHQFCE GDGSLFSTLF TFGSITFVLI SVIGLVLGSI
HEFQVPIYKK GGKSERISNW SIVENENIIW EPHPIFGYVE TVCIIWFTVE FIVRLAVTPN
RFQFLVGIMN IVDMIAIIPF YLELGLALFG IDVASLSDIK GALLVVRVLR VLRVVRILKL
GRYSSGMRTF ALTLKSSARQ LGMMGMVLST GVVFFSTLLY FVEKDEKDTP FTSIPAAFWW
AIVTMTTVGY GDYVPVTVPG KLIASGAIIS GVLVLALPIT IIVDNFMKVS GNIDTQE
//
