ID H2KZQ7_CAEEL Unreviewed; 501 AA.
AC H2KZQ7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|EMBL:CCD69346.1};
GN Name=exp-2 {ECO:0000313|EMBL:CCD69346.1,
GN ECO:0000313|WormBase:F12F3.1d};
GN ORFNames=CELE_F12F3.1 {ECO:0000313|EMBL:CCD69346.1}, F12F3.1
GN {ECO:0000313|WormBase:F12F3.1d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD69346.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD69346.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69346.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284605; CCD69346.1; -; Genomic_DNA.
DR RefSeq; NP_001023792.1; NM_001028621.3.
DR AlphaFoldDB; H2KZQ7; -.
DR SMR; H2KZQ7; -.
DR EnsemblMetazoa; F12F3.1d.1; F12F3.1d.1; WBGene00001374.
DR GeneID; 179003; -.
DR KEGG; cel:CELE_F12F3.1; -.
DR AGR; WB:WBGene00001374; -.
DR WormBase; F12F3.1d; CE37631; WBGene00001374; exp-2.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00001374; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; H2KZQ7; baseline and differential.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18317; BTB_POZ_Kv; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF133; PROTEIN CBR-EXP-2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 1: Evidence at protein level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Proteomics identification {ECO:0007829|EPD:H2KZQ7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 312..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..169
FT /note="Potassium channel tetramerisation-type BTB"
FT /evidence="ECO:0000259|Pfam:PF02214"
FT DOMAIN 218..476
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 501 AA; 56678 MW; 919EF264720BA665 CRC64;
MKMAQARVTG NMISGAAQQH KKRLVPLRRT DAMTVAERRN YQILDDIFRS GASDCFQQVS
SADNGSPQFL KLNIGGTSFM ILIDAILRAD TTTFLSRFVQ LTHTARLKVA DAYISADDAY
YFQRSPTSFE AVFQYYATGV VHRPSEICPA SFLSELDFWR ISHQHVGSCC ADIIPQKREE
EKEEEKVDDT TFDKLMCGKL RRRMWTFLER PGSSMQAKAF ELSSTLFVAI SVMGLSFGTI
PDFQVTHLMP PHNETVVLPN GTVTVVQKVE QMRVEHPAFV FTERICIAFF TVEYCLRFFA
APRKLRFALK PLNLVDLLAI VPFYLELLLT LCGVDDRKLR DLRWAFLVVR ILRVLRVIRI
IKLGRFSSGL QTFGMTLQRS QKQLQMMTIV LLTGVVFFST MIYFLEKDEE GTPFTSIPAA
YWWCIVTMTT VGYGDAVPAT TMGKIIASAA IMCGVLVLAL PITIIVDNFI KVAQDEQQAE
QQKNDQQSEQ LALEAMLNAH D
//
