ID   H2L0P4_CAEEL            Unreviewed;       613 AA.
AC   H2L0P4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   24-JAN-2024, entry version 85.
DE   SubName: Full=Pleckstrin homology domain-containing family G member 7 {ECO:0000313|EMBL:CCD73548.1};
GN   Name=prhg-1 {ECO:0000313|EMBL:CCD73548.1,
GN   ECO:0000313|WormBase:Y95B8A.12b};
GN   ORFNames=CELE_Y95B8A.12 {ECO:0000313|EMBL:CCD73548.1}, Y95B8A.12
GN   {ECO:0000313|WormBase:Y95B8A.12b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73548.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD73548.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73548.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284601; CCD73548.1; -; Genomic_DNA.
DR   RefSeq; NP_001032993.1; NM_001037904.2.
DR   AlphaFoldDB; H2L0P4; -.
DR   SMR; H2L0P4; -.
DR   EPD; H2L0P4; -.
DR   EnsemblMetazoa; Y95B8A.12b.1; Y95B8A.12b.1; WBGene00022391.
DR   GeneID; 190810; -.
DR   AGR; WB:WBGene00022391; -.
DR   WormBase; Y95B8A.12b; CE39077; WBGene00022391; prhg-1.
DR   OrthoDB; 2873655at2759; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00022391; Expressed in larva and 3 other cell types or tissues.
DR   ExpressionAtlas; H2L0P4; baseline and differential.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd13245; PH_PLEKHG7; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR040181; PKHG5/7.
DR   PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR   PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR   Pfam; PF16652; PH_13; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:H2L0P4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT   DOMAIN          177..371
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          425..546
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          12..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        585..602
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  70918 MW;  5FE2FF75678F06A8 CRC64;
     MVDLQLFTPL IRYSEPEEGE PQTIHPNKEQ LSRRHAIIPD QPSENQETSS QGCCSSDNVI
     IVPHVQISPN ESHLFNRAIS SGGGLLADLQ RATIASQAFY AEASEPQKNR SPWILKRLYE
     WSGRAKRREI IKHVQAALET SKDHEIEDDE LEKLLPVSFE EMFMGDETTT IPSSKHKYLQ
     AVWELFHTEL VFLYRQLFVL RDVYKEPLKR CQVEGCLLLV EPDLLFGNLD QLCRISRTFC
     QSFLSLLSTV DKENWDCTQL VVDLFERFSK GPSTISAYQA YCINYKATME YLGSIRQKEE
     RFTEFERICL ADERCFRLQL EDLLIAPLQR ITRLPILLRE IHKRSEEEES KGKVEKVIDT
     MTESLRSIDD SVQWLHNFER LQQLQTQVVW PNISDLEPKS YVPDFLRVAL SRQFCENLLA
     HPRRKLIHEG PLELVENGRT VDMYAFLFND MFVLTKTKKC ASKLKVKGVP IGKSEHYIVQ
     RQPVPLDSCV FCDADSNDQA TPMSLKFAFV IIHLTRYYQV VGIYTLQAAD KADKELWIEK
     FQESIENYES IQLKDMLKCT PLFSSLSLRR CSSSRLMSKS ESNSPQLPKE KEKEKEEKKE
     CCSSSTCNNQ APP
//