ID H2L0P4_CAEEL Unreviewed; 613 AA.
AC H2L0P4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE SubName: Full=Pleckstrin homology domain-containing family G member 7 {ECO:0000313|EMBL:CCD73548.1};
GN Name=prhg-1 {ECO:0000313|EMBL:CCD73548.1,
GN ECO:0000313|WormBase:Y95B8A.12b};
GN ORFNames=CELE_Y95B8A.12 {ECO:0000313|EMBL:CCD73548.1}, Y95B8A.12
GN {ECO:0000313|WormBase:Y95B8A.12b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73548.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD73548.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73548.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284601; CCD73548.1; -; Genomic_DNA.
DR RefSeq; NP_001032993.1; NM_001037904.2.
DR AlphaFoldDB; H2L0P4; -.
DR SMR; H2L0P4; -.
DR EPD; H2L0P4; -.
DR EnsemblMetazoa; Y95B8A.12b.1; Y95B8A.12b.1; WBGene00022391.
DR GeneID; 190810; -.
DR AGR; WB:WBGene00022391; -.
DR WormBase; Y95B8A.12b; CE39077; WBGene00022391; prhg-1.
DR OrthoDB; 2873655at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00022391; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; H2L0P4; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13245; PH_PLEKHG7; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:H2L0P4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 177..371
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 425..546
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 12..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 70918 MW; 5FE2FF75678F06A8 CRC64;
MVDLQLFTPL IRYSEPEEGE PQTIHPNKEQ LSRRHAIIPD QPSENQETSS QGCCSSDNVI
IVPHVQISPN ESHLFNRAIS SGGGLLADLQ RATIASQAFY AEASEPQKNR SPWILKRLYE
WSGRAKRREI IKHVQAALET SKDHEIEDDE LEKLLPVSFE EMFMGDETTT IPSSKHKYLQ
AVWELFHTEL VFLYRQLFVL RDVYKEPLKR CQVEGCLLLV EPDLLFGNLD QLCRISRTFC
QSFLSLLSTV DKENWDCTQL VVDLFERFSK GPSTISAYQA YCINYKATME YLGSIRQKEE
RFTEFERICL ADERCFRLQL EDLLIAPLQR ITRLPILLRE IHKRSEEEES KGKVEKVIDT
MTESLRSIDD SVQWLHNFER LQQLQTQVVW PNISDLEPKS YVPDFLRVAL SRQFCENLLA
HPRRKLIHEG PLELVENGRT VDMYAFLFND MFVLTKTKKC ASKLKVKGVP IGKSEHYIVQ
RQPVPLDSCV FCDADSNDQA TPMSLKFAFV IIHLTRYYQV VGIYTLQAAD KADKELWIEK
FQESIENYES IQLKDMLKCT PLFSSLSLRR CSSSRLMSKS ESNSPQLPKE KEKEKEEKKE
CCSSSTCNNQ APP
//