ID H2L2C3_CAEEL Unreviewed; 963 AA.
AC H2L2C3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Rap-GAP domain-containing protein {ECO:0000313|EMBL:CCE71437.1};
GN Name=sipa-1 {ECO:0000313|EMBL:CCE71437.1,
GN ECO:0000313|WormBase:T27F2.2c};
GN ORFNames=CELE_T27F2.2 {ECO:0000313|EMBL:CCE71437.1}, T27F2.2
GN {ECO:0000313|WormBase:T27F2.2c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCE71437.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCE71437.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCE71437.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284605; CCE71437.1; -; Genomic_DNA.
DR RefSeq; NP_001256345.1; NM_001269416.1.
DR AlphaFoldDB; H2L2C3; -.
DR SMR; H2L2C3; -.
DR EnsemblMetazoa; T27F2.2c.1; T27F2.2c.1; WBGene00012100.
DR GeneID; 179596; -.
DR AGR; WB:WBGene00012100; -.
DR WormBase; T27F2.2c; CE46551; WBGene00012100; sipa-1.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00012100; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; H2L2C3; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF70; RAP-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Proteomics identification {ECO:0007829|EPD:H2L2C3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 363..580
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 22..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 107724 MW; 174B223809EF8CB9 CRC64;
MSSTTSSVRS ANRTRSLCHH LHHQPLLVSG SSTGSPPIGG SMDEGSSAST SSSATARALD
MFNRRGSVLA VVIAGNTAAD VLPPSAGVPN TSAVSSSSGV ISADQPSSTN SDNDTETFNE
WRPPFPRLSA YQDCLSLAAA WGLGMHPNGL DDKPTGASQA QSPSEDDSGD GKFNELLASC
PAFRNELGWE PTRRFALSRH TFDMAHTDAH ECETWMREHS ASEAGILEDV SNVYLGGRLC
AARQPKTVIE PQDIGSYYYR HCFISKNHIE YLGMDDILGP ISISMVREIV DRKESYSIYR
MIVRISDQKT IRVAVPEEAL STPEGSDRAT RPLMRELLEI VCPKISFGIL RPSIQSPRVE
ELIMKIDEQP IYTRYKVGIM LCKNEQSTEE QMYNNEFSTP SFDEFLDFLG QRVTLKGFEA
YKGGLDTRGD TTGTHSIYSE YQAHEIMFHV STLLPFTPSN RQQLSRKRHI GNDMVTIVFQ
EPGALPFSPI TVRSHFQHVF IIVRVHNECS ENVTYSVAVS RSKDVPAFGP PVPKGACFSK
CAEFHDWLLT KIINAENAVH RSKKFATMAA RTRREALRDL VENYVGPHQN EGASKIASRF
LGGSVKRKER HNPKPTNHVM RGALSWLVDV HDYSTNQRIS CVLGVAQDWI VLLERPSGTV
LFSTPTHSII GWATSDTGLK LYYDHGDQLL LRCYSETCTD SELNELIRRL ENVTKGDEAK
EVVLRRLKTT DNWGFHVQDE GVVTDVEMYQ LAWKAGIRQG SRIVEMDSMP ISTLSFDKIC
DQLAVSECVR LLMISPSSDG SPRRGCEDPN CPAVKGIEQM LTPDAFAKQP ITFTATKKTI
EQRANNISNN RPNTLSSASV HDNMCTLLNP PKYLNRAQSD EQLRSPLMDE LNRKAPLSAR
ESTNERESSE LVRIQTHLER TVQEKRALEM LAQQLKKQLI QERQSHDNTK REMERLKKMY
EKK
//
