ID H2L2F0_CAEEL Unreviewed; 1257 AA.
AC H2L2F0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Sushi domain-containing protein {ECO:0000313|EMBL:CCE72111.1};
GN Name=cfh-1 {ECO:0000313|EMBL:CCE72111.1};
GN ORFNames=CELE_F36H2.3 {ECO:0000313|EMBL:CCE72111.1}, F36H2.3
GN {ECO:0000313|WormBase:F36H2.3g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCE72111.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCE72111.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCE72111.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; BX284601; CCE72111.1; -; Genomic_DNA.
DR RefSeq; NP_001251043.1; NM_001264114.1.
DR AlphaFoldDB; H2L2F0; -.
DR EnsemblMetazoa; F36H2.3g.1; F36H2.3g.1; WBGene00009500.
DR GeneID; 185381; -.
DR AGR; WB:WBGene00009500; -.
DR WormBase; F36H2.3g; CE46676; WBGene00009500; -.
DR OrthoDB; 2882793at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00009500; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; H2L2F0; baseline and differential.
DR CDD; cd00033; CCP; 10.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 11.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00084; Sushi; 8.
DR SMART; SM00032; CCP; 15.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 13.
DR PROSITE; PS50923; SUSHI; 11.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302};
KW Proteomics identification {ECO:0007829|EPD:H2L2F0,
KW ECO:0007829|PeptideAtlas:H2L2F0};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1257
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003564418"
FT DOMAIN 191..255
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 275..342
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 346..407
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 429..491
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 500..559
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 638..700
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 709..771
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 779..841
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 850..913
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1122..1184
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1195..1256
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 313..340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 502..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 884..911
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1227..1254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1257 AA; 129240 MW; 6D0D27AEE6DD1984 CRC64;
MKIIIFCFIL ATLTASVTFG RKCDADLKPE KLVVVGVWKR GFDNSTAQYR ISDEDLSVRG
YERTESDKGS STVMLARHPE GCVINECGVR LSAMMQNNGA ILHTDYRMIR MNDSTMNNIE
DEFYCAEKNN FCGADVPIYR LVKHSLTGPH YAYTFNDVGQ SLPGYEKEFF PLCFAWRQTP
SVVLFNSTDD GVCLTLPEVQ NGKILYSNDQ LNVFSIGTSA TLECHQGFAG NGPSSLVCTK
NGWYPKREDL GSCVRLEQSN KSRLLVASDV TPTSSSCRVP SSTPNGNIVY SANVATSTSI
NSVPTATRAT VLCSLGHVPT TSVTSSKCVD GEWEPSLPTC LSLLDIKCPI LSAPRNGELV
FTNSVKSPYS LNSVISLKCD RNYFGTGNLT STCTSTGWDQ KIGQCEPVGI RRLSESHRYR
IRRQASTGAV CAAIANPANG NLLYMQSNPT VQYSSGTSAY LMCNLGYSLS GSVSTLCSNG
VWSPSIGQCT NALALGQTTG NCEAIPTRIN GTITYSSFGT YTSGTIATLA CNLMNTVSGS
STSTCLSGVW NPTIGNCVSS GGTGGTGTTC PNPTVINGQI TYNQGNTFDT TRPALTTATL
TCNSGYTRNG NYISTCLGGV FTPTLGTCTF GTSGSTGTAC INPIIMNGQI TYSQGNTYDI
TRPSGTAATL TCNSGYTISG SSQSTCTNGA FSPTLGTCNF GSSTGGAGTT CPNPTVVNGQ
VTYNQGNTFD ATRPALTIAT LTCNSGYTIS GTSTSTCING VFTPTLGTCT FGTSGSTGTA
CINPIIMNGQ ITYSQGNTYD ITRPAGTTAT LTCSSGYTVS GTSVSTCTNG IFTPTLGTCT
LGSSTGGTGI QCTAMIAPLG GSVIYSNGGT MGPFPSGTTV TGSCTNGGAI TGASTATCSN
GMWNPTFLGT CSLIGGSTTG QCSALTIPSG AQATYSPFSL STTSFTSGTV ATVTCTTGGS
MLGTSTCTNG LWSPAIMGTC SGTGTGNTCS ALTRPVGETV TYDGTTSFAT TFNSGVIARV
TCSNGTQIGQ STCLVGQWTP AITATCSGSS TAVGSQCIGV IVPTNAQVTY SDGSMVLHSA
GTTATLTCLN SATLTGSSYS SCSNGVWTPT LGSCTSSGTG TGPCYTPPLT PVGATLTYSS
GYFAPWTAGS TATMSCPAGQ TVIGTSISYC TNSAWSPALG SCSGSSVGQA STTTTTCSFL
PIAPPYGSIV TSQTAPFSAG TMVTLQCDNG YQIQGNNATS TCTNGVFSEI TATCIKN
//
