ID H2L2V2_ORYLA Unreviewed; 1035 AA.
AC H2L2V2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSORLP00000000052.2};
GN Name=ect2 {ECO:0000313|Ensembl:ENSORLP00000000052.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000052.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000052.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000052.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000052.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000052.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011492805.1; XM_011494503.1.
DR AlphaFoldDB; H2L2V2; -.
DR Ensembl; ENSORLT00000000052.2; ENSORLP00000000052.2; ENSORLG00000000041.2.
DR GeneID; 101157762; -.
DR CTD; 1894; -.
DR eggNOG; KOG3524; Eukaryota.
DR GeneTree; ENSGT00940000156299; -.
DR HOGENOM; CLU_008187_0_0_1; -.
DR OrthoDB; 6929at2759; -.
DR TreeFam; TF101161; -.
DR Proteomes; UP000001038; Chromosome 4.
DR Bgee; ENSORLG00000000041; Expressed in animal zygote and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR CDD; cd01229; PH_Ect2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR026817; Ect2.
DR InterPro; IPR049396; ECT2_BRCT0.
DR InterPro; IPR049395; ECT2_PH.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF21243; ECT2_BRCT0; 1.
DR Pfam; PF21242; ECT2_PH; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 179..251
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 267..354
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 443..632
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 920..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 116071 MW; 08D248B1A6B87DD4 CRC64;
MADSSMLSLG AARSLLVDSS VCDSRIAEVT SDHTFLAAAC EDEEEMLPKV ETRVVLVGEA
GRNQVLVKTL QAIRMMEVPV VKIREGDASA KEKMMIKSIV SMDINTPFLV TDNVQEFAEG
DGAEFETVFV LTDFDTSDYS FLHRRDNRIV GPPVVFHCAA KEEPMLFSCR PLYCTAMLNL
SLCLTGFRNK EEMKNLVNLV HHMGGTIRKD FSTKVTHLVA YSTHGEKYRL AVCMGTPILT
PLWIQKSWER RDDVDFHAGQ EEFRSEFKVP PFQDCVLSFL GFSEEEKANM EERTLKHGGR
YLEVGDERCT HLVVEENSVR ELLTSSKKLY VVKQEWFWGS IQMDARAGES MYLYEKNDSP
AMKKAVSLLS LTTPNSNRKR RRLKDTLAQL SKETEMSPFP PPRKRASAEN SLSIGSLLDI
SNTPETCKGL TESSTPVLSK QSARWQVSRE LYQTESNYVD ILSTILQLFK HPLEKEGQVG
GAILAQEEVK TIFGNIPDIF EVHTQIKNDL EELLSDWSEN RSVGNIFLKY SKELVKAYPP
FVNFFEMSKE TIVRCEKQKP RFHAFLKINQ AKPECGRQTL VELLIRPVQR LPSVALLLND
IRKHTSDDNP DKITLEKAIE SLKEVMTHIN EDKRKTEGQK QIFDVVYEVD GCPANLLSSH
RSLVQKVETV ALGDQPCDRG EQVTLFLFND CLEIARKRHK VINTFKSPLG QTRPPPPLKH
ISLMPLSQIR RVLDLQDTEE CVNAFALVVR PPTEQENLLF SFQLVGEETV KSAWLRTLCR
HVANTICRAD AEDLIQITDP DSLQVSTKDM DSTLSKASRA IKKTSKKVTR AFSFTKTPKR
AIQRAFMANT TPDKKTQRLS CENRVCSSAT LAMSRSTSTF SLSDSAKSSA VVQRSNSLDH
PPLRTRVPVC ICTPAPSPSS SSPSYPAASG NQESQSPSST PSLTLAAQPQ STLSIPHTST
YVAHCTSTVE NDSKFVHSQP KSGQHVFRSP SSIRLQARAA ASHQGNVQTV TICERRRPEH
VDPHKAIGPR SETLL
//
