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Database: UniProt
Entry: H2L3T1_ORYLA
LinkDB: H2L3T1_ORYLA
Original site: H2L3T1_ORYLA 
ID   H2L3T1_ORYLA            Unreviewed;      1850 AA.
AC   H2L3T1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Latent-transforming growth factor beta-binding protein 1 {ECO:0000313|Ensembl:ENSORLP00000000411.2};
GN   Name=LOC101168560 {ECO:0000313|Ensembl:ENSORLP00000000411.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000411.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000000411.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000411.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000000411.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000411.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the LTBP family.
CC       {ECO:0000256|ARBA:ARBA00038081}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 8090.ENSORLP00000000411; -.
DR   Ensembl; ENSORLT00000000411.2; ENSORLP00000000411.2; ENSORLG00000000336.2.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00940000158234; -.
DR   HOGENOM; CLU_001884_1_0_1; -.
DR   InParanoid; H2L3T1; -.
DR   OrthoDB; 354414at2759; -.
DR   TreeFam; TF317514; -.
DR   Proteomes; UP000001038; Chromosome 13.
DR   Bgee; ENSORLG00000000336; Expressed in heart and 11 other cell types or tissues.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0050431; F:transforming growth factor beta binding; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   CDD; cd00054; EGF_CA; 11.
DR   Gene3D; 2.10.25.10; Laminin; 16.
DR   Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR017878; TB_dom.
DR   InterPro; IPR036773; TB_dom_sf.
DR   PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07645; EGF_CA; 13.
DR   Pfam; PF00683; TB; 4.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00179; EGF_CA; 15.
DR   SUPFAM; SSF57196; EGF/Laminin; 4.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR   SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 9.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 6.
DR   PROSITE; PS50026; EGF_3; 10.
DR   PROSITE; PS01187; EGF_CA; 6.
DR   PROSITE; PS51364; TB; 4.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1850
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017187647"
FT   DOMAIN          375..407
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          545..586
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          610..646
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          660..716
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          924..961
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1002..1039
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1080..1121
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1122..1163
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1164..1199
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1349..1402
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1420..1462
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1463..1502
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1514..1567
FT                   /note="TB"
FT                   /evidence="ECO:0000259|PROSITE:PS51364"
FT   DOMAIN          1804..1848
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          21..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          287..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..876
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1576..1747
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..252
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..510
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1655..1670
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1692..1706
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        379..389
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        397..406
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        928..938
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1006..1016
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1467..1477
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1850 AA;  198096 MW;  D4063550C0D0192F CRC64;
     MRLPLLCVWA GWMLMVSGDA QREDGGAPAA RESRRSGWRR ESSRGAGDPD GGSRRTAGGP
     HVPGPPCCIR WSLSTQTRKC IKARCPPPCR NGTSCRQPNT WWCRPGFHGN RCRLSAAARS
     PTRATPTRTG TTPGSQVKRL LTRATEEDTG SDPVRSGSSG AAALGRKEKR GRVLKKLGSP
     EETQTSSGGP GLTREGPSSE KASLHPKVEE RRSGPKRLEQ KLSPGPNGGR VLTAGRRRWE
     EKKRREVKQK PSLREVQWML QRKTSGPGGP GGGMATLLMK HIAKEKRRLH SLTSSNSSRK
     TFSQRGQESI STPTGGGRGR DRIRVMFTPT ICKVRCSQDR CVNHCERGNA TTVYSSSSGE
     GGAGVRDGSH GPGFRVFLCP LLCKNGGVCI QQDRCLCPAN FTGKFCHIPV TPEAHFTAGR
     TSSINEIIKP ALLSAATTNQ DLTHSEFLLP LGQNQEAQRP GVPASSMVKV RVQHPPEASV
     KVHQVVKVSG SGPTQRALSS FSSGSAGAPA PSPDLSTAPP STGSSGVQAQ TVRGGGTYTQ
     HSGFKYCFRE VRDGQCSSPL PGLRSRDVCC SGMGKAWGLT DCVLCPKNAG QSNSSCPAGF
     GRVNGTQCVD VNECLQPGLC ENGICVNTRG SYSCVCRVGF ILDATHGVCI SHSVISEEKG
     QCYRVLDQGR GPSSCSLPIA RNITKQICCC SRVGKAWGAD CQRCPHFGSV SFKEICPAGP
     GYHYSASTLQ VTQRVSEHLD PTGTESGSSS SRTSISQQKP SSSGTTSSSF SSFGARPSPP
     HLEIRPRPEP RPTAGSPRQP ASGGAIVLQG KPAVQQTQPG SSVSQLAQAR PQSPSGGTQG
     SQPSFRSQPS QFPSGGDLFP PAVLPKNPAN PTARPARVQP LKGVCETRPG VCGRGHCLDL
     PGGKHSCLCE SGYEHGPQRT TCQDVDECLQ NPCSNSRCEN TPGSYRCVCR HGYRLSGNTC
     TDVDECVDPL RCPGQECVNT LGSYRCTSCQ PGYGLLNGLC TDIDECRQSP CSNARCENTP
     GSYRCVCRPG YRLQNDTCAD MDECAEPSRC NGQMCVNSAG SYRCVSCRSG YKLTNRQCTD
     VDECESAAAC EADRRCVNTA GSFRCECLPG YQASSLGRQC RDINECLEGD FCFSGGECLN
     TPGSYMCVCS QGFTLSSNGT ACKDVDECLK PGVCSDGRCV NTDGSFHCRC ANGFASNPER
     TACLDVDECI SSNGSVCGSQ RCENTIGSYR CLTSCEAGYR VQPDGSCADE DECASQPGVC
     GTARCENLKG GFVCRCDITG QVFEATSRRC VSAAPRLTET GRGTQILSSA FSSAFHVRMV
     ELAPPLLAPT PPPVSAPTPL PEARPGELRE CYYNLANRGS CSLLAANTTQ QECCCTVGEG
     WGLGCQYYTC PPANTAEFLA LCLSGRGYVT AGPGVFNYRD VDECKRFQPQ VCKNGVCVNN
     IPGYRCYCYS GYVYNSTLLE CVDHDECEEE TCVGGVCVNT VGSYYCTCPT HLVLDETQRN
     CVNSSHSSMD ENLSVCWQHV SADLLCQSPL LGGQVTFTDC CCMYGEGWGM GCALCPSSDS
     EEYAALCSSF APPFPDSYPE PPGPETRLLL ESGRGAPPYG SDLYTRTLVP SRDFSRPDYD
     DYSPAGGVRS GFGGRTPGTS SLPEDAYRPS DYSSYYSEGD YSSPDSSAPQ TPSFRLPPDP
     RSEIGFGARP FPPSRPDGPP LSLAPLPGSP YDDQEEEDEM TWRPSPPFPP FTDRNRGGGG
     AGGRGAPRRL YERRYELYAG LSAAEDCGIL HGCENGRCIR VAEGYTCDCY HGYELDMTSM
     TCIDVNECED GVGLEFPCVN ARCVNTEGSF RCVCRRGYVV SRRRNHCVAA
//
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