ID H2L3T1_ORYLA Unreviewed; 1850 AA.
AC H2L3T1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Latent-transforming growth factor beta-binding protein 1 {ECO:0000313|Ensembl:ENSORLP00000000411.2};
GN Name=LOC101168560 {ECO:0000313|Ensembl:ENSORLP00000000411.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000411.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000411.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000411.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000411.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000411.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the LTBP family.
CC {ECO:0000256|ARBA:ARBA00038081}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 8090.ENSORLP00000000411; -.
DR Ensembl; ENSORLT00000000411.2; ENSORLP00000000411.2; ENSORLG00000000336.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000158234; -.
DR HOGENOM; CLU_001884_1_0_1; -.
DR InParanoid; H2L3T1; -.
DR OrthoDB; 354414at2759; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000000336; Expressed in heart and 11 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050431; F:transforming growth factor beta binding; IBA:GO_Central.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 11.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 13.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1850
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017187647"
FT DOMAIN 375..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 545..586
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 610..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 660..716
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 924..961
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1002..1039
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1080..1121
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1122..1163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1164..1199
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1349..1402
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1420..1462
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1463..1502
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1514..1567
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1804..1848
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 21..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1655..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1706
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 379..389
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 928..938
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1006..1016
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1467..1477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1850 AA; 198096 MW; D4063550C0D0192F CRC64;
MRLPLLCVWA GWMLMVSGDA QREDGGAPAA RESRRSGWRR ESSRGAGDPD GGSRRTAGGP
HVPGPPCCIR WSLSTQTRKC IKARCPPPCR NGTSCRQPNT WWCRPGFHGN RCRLSAAARS
PTRATPTRTG TTPGSQVKRL LTRATEEDTG SDPVRSGSSG AAALGRKEKR GRVLKKLGSP
EETQTSSGGP GLTREGPSSE KASLHPKVEE RRSGPKRLEQ KLSPGPNGGR VLTAGRRRWE
EKKRREVKQK PSLREVQWML QRKTSGPGGP GGGMATLLMK HIAKEKRRLH SLTSSNSSRK
TFSQRGQESI STPTGGGRGR DRIRVMFTPT ICKVRCSQDR CVNHCERGNA TTVYSSSSGE
GGAGVRDGSH GPGFRVFLCP LLCKNGGVCI QQDRCLCPAN FTGKFCHIPV TPEAHFTAGR
TSSINEIIKP ALLSAATTNQ DLTHSEFLLP LGQNQEAQRP GVPASSMVKV RVQHPPEASV
KVHQVVKVSG SGPTQRALSS FSSGSAGAPA PSPDLSTAPP STGSSGVQAQ TVRGGGTYTQ
HSGFKYCFRE VRDGQCSSPL PGLRSRDVCC SGMGKAWGLT DCVLCPKNAG QSNSSCPAGF
GRVNGTQCVD VNECLQPGLC ENGICVNTRG SYSCVCRVGF ILDATHGVCI SHSVISEEKG
QCYRVLDQGR GPSSCSLPIA RNITKQICCC SRVGKAWGAD CQRCPHFGSV SFKEICPAGP
GYHYSASTLQ VTQRVSEHLD PTGTESGSSS SRTSISQQKP SSSGTTSSSF SSFGARPSPP
HLEIRPRPEP RPTAGSPRQP ASGGAIVLQG KPAVQQTQPG SSVSQLAQAR PQSPSGGTQG
SQPSFRSQPS QFPSGGDLFP PAVLPKNPAN PTARPARVQP LKGVCETRPG VCGRGHCLDL
PGGKHSCLCE SGYEHGPQRT TCQDVDECLQ NPCSNSRCEN TPGSYRCVCR HGYRLSGNTC
TDVDECVDPL RCPGQECVNT LGSYRCTSCQ PGYGLLNGLC TDIDECRQSP CSNARCENTP
GSYRCVCRPG YRLQNDTCAD MDECAEPSRC NGQMCVNSAG SYRCVSCRSG YKLTNRQCTD
VDECESAAAC EADRRCVNTA GSFRCECLPG YQASSLGRQC RDINECLEGD FCFSGGECLN
TPGSYMCVCS QGFTLSSNGT ACKDVDECLK PGVCSDGRCV NTDGSFHCRC ANGFASNPER
TACLDVDECI SSNGSVCGSQ RCENTIGSYR CLTSCEAGYR VQPDGSCADE DECASQPGVC
GTARCENLKG GFVCRCDITG QVFEATSRRC VSAAPRLTET GRGTQILSSA FSSAFHVRMV
ELAPPLLAPT PPPVSAPTPL PEARPGELRE CYYNLANRGS CSLLAANTTQ QECCCTVGEG
WGLGCQYYTC PPANTAEFLA LCLSGRGYVT AGPGVFNYRD VDECKRFQPQ VCKNGVCVNN
IPGYRCYCYS GYVYNSTLLE CVDHDECEEE TCVGGVCVNT VGSYYCTCPT HLVLDETQRN
CVNSSHSSMD ENLSVCWQHV SADLLCQSPL LGGQVTFTDC CCMYGEGWGM GCALCPSSDS
EEYAALCSSF APPFPDSYPE PPGPETRLLL ESGRGAPPYG SDLYTRTLVP SRDFSRPDYD
DYSPAGGVRS GFGGRTPGTS SLPEDAYRPS DYSSYYSEGD YSSPDSSAPQ TPSFRLPPDP
RSEIGFGARP FPPSRPDGPP LSLAPLPGSP YDDQEEEDEM TWRPSPPFPP FTDRNRGGGG
AGGRGAPRRL YERRYELYAG LSAAEDCGIL HGCENGRCIR VAEGYTCDCY HGYELDMTSM
TCIDVNECED GVGLEFPCVN ARCVNTEGSF RCVCRRGYVV SRRRNHCVAA
//