ID H2L3Y0_ORYLA Unreviewed; 503 AA.
AC H2L3Y0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000256|PIRNR:PIRNR037185};
GN Name=cetp {ECO:0000313|Ensembl:ENSORLP00000000460.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000460.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000460.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000460.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000460.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000460.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC the net movement of cholesteryl ester from high density
CC lipoproteins/HDL to triglyceride-rich very low density
CC lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC VLDL to HDL. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037185}.
CC Note=Secreted in plasma. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|PIRNR:PIRNR037185}.
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DR AlphaFoldDB; H2L3Y0; -.
DR STRING; 8090.ENSORLP00000000460; -.
DR Ensembl; ENSORLT00000000460.2; ENSORLP00000000460.2; ENSORLG00000000375.2.
DR eggNOG; KOG4160; Eukaryota.
DR GeneTree; ENSGT01100000263545; -.
DR HOGENOM; CLU_878630_0_0_1; -.
DR InParanoid; H2L3Y0; -.
DR OrthoDB; 5355726at2759; -.
DR TreeFam; TF333484; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000000375; Expressed in liver and 11 other cell types or tissues.
DR GO; GO:0034364; C:high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR GO; GO:0031210; F:phosphatidylcholine binding; IBA:GO_Central.
DR GO; GO:0005548; F:phospholipid transporter activity; IBA:GO_Central.
DR GO; GO:0017129; F:triglyceride binding; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR GO; GO:0008203; P:cholesterol metabolic process; IBA:GO_Central.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IBA:GO_Central.
DR GO; GO:0034374; P:low-density lipoprotein particle remodeling; IBA:GO_Central.
DR GO; GO:0046470; P:phosphatidylcholine metabolic process; IBA:GO_Central.
DR GO; GO:0055091; P:phospholipid homeostasis; IBA:GO_Central.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR GO; GO:0070328; P:triglyceride homeostasis; IBA:GO_Central.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR GO; GO:0034197; P:triglyceride transport; IBA:GO_Central.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IBA:GO_Central.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR PANTHER; PTHR47616:SF1; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 1.
DR SMART; SM00328; BPI1; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|PIRNR:PIRNR037185};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037185-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR037185};
KW Lipid transport {ECO:0000256|PIRNR:PIRNR037185};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037185};
KW Signal {ECO:0000256|PIRNR:PIRNR037185};
KW Steroid metabolism {ECO:0000256|PIRNR:PIRNR037185};
KW Sterol metabolism {ECO:0000256|PIRNR:PIRNR037185};
KW Transport {ECO:0000256|PIRNR:PIRNR037185}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT CHAIN 25..503
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT /id="PRO_5017107151"
FT DOMAIN 43..269
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DISULFID 171..212
FT /evidence="ECO:0000256|PIRSR:PIRSR037185-50"
SQ SEQUENCE 503 AA; 55360 MW; 153BD7BA6FA5776A CRC64;
MSRKESAPVI PLLLLPLFLS FGRAYSCLED PAEAYRLSGA VCRLTYPAAA VLNEKTTKVI
EAAFQHARYP SMQGEKSLLL IGKVSFGLEN LEIHNLSIGR SEFELVPGKG IALKISNVSA
VFKGTIQYGY GSWLVNLAQS LDLEIESQID LGINPRLYCG KGKVAADTSD CYLRFHKLRL
HLQGDKEPNW LKKLFTDFIT FTVKLVVKGQ ICKEINKLAD ILSDFIQDTA AHFLSDGDIS
VDIGVTTAPA ITANYIESYH KGLTNYNNTT SALNESAFHP SQLTEDRMLF FWFSDELFNP
LIAAAHHDGR FHLNVSAGEL SELLKTSLSN VTVDSIQTCL AGASAELRVW SSSVPRLHTS
NTGSRVTAQA CGELHCGGQG PPALFFETSV LVDVTASYSD KKLFLHGSPK KISVLQAEIP
SQNKVLQDEA QVSFIKEAVE KVGIPKVLSV LQVEITRLLD KQGANLFDII DPEVLPRDGF
TVTKMDFGFP HHLLVDFLQK TLQ
//
