ID H2L3Z0_ORYLA Unreviewed; 666 AA.
AC H2L3Z0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000470.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000470.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000470.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000470.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000470.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2L3Z0; -.
DR Ensembl; ENSORLT00000000470.2; ENSORLP00000000470.2; ENSORLG00000022467.1.
DR GeneTree; ENSGT01100000263487; -.
DR HOGENOM; CLU_065715_0_0_1; -.
DR InParanoid; H2L3Z0; -.
DR TreeFam; TF352120; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000022467; Expressed in intestine and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF151; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12-RELATED; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 127..261
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 666 AA; 75603 MW; AD516A2A02892332 CRC64;
PFSELQPVRT HPLIYHTFLL HHRKRHLGHR GQGTPRSAAP VCRREVQSGL QKKFQCVFEG
MAKAGNPTLL NEIYTELFIT EGGRGELNEE HEVRQIEAAS RKADRAETSI RQEELFQLPA
GRPEPIRTVM TKGVAGIGKT VLTQKFTLDW AEGKAHQNLH FTFPFTFREL NVLKEEKFSL
VELVHHFFPE TKQAGICSFE DFQVLFIFDG LDESRLPLDF HKTRILKDPR KSTSVADLLT
NLIRGNLLPS ARLWITTRPA AANQIPAKCV DMVTEVRGFN DPQKEEYFRK RFRDEEQASR
IISHIQRSRS LHIMCHIPVF CWITATVLED LMKSRGRGEL PKSLTEMYIH FLVVQAKVKK
VKYDGGYETD PHWSPESRKM MESLGKLAFE QLQKGNLIFY ESDLTECGID IRAASVYSGV
FTQVFREERG LYQDKVFCFI HLSVQEFLAA LHSAVKKALQ SPNGHLDLFL RFLLGLSLQT
NQSLLRGLLT QTGSSSQTNQ ETVQFLKEKI SEDLPAEKSI NLFHCLNELN DGSLVEEIQQ
VLRSGRLSTK KLSPAQWSAL VFILLSSEED LEEFDLNKYS GSEEALLRLL PVIKASNKAL
SQSSRLRHLD LSNNNLQDSG VKLLSAGLES PDCKLETLRS VSFNPCAILD DPTLILTCSP
YHDKAG
//
