ID H2L4I9_ORYLA Unreviewed; 616 AA.
AC H2L4I9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Inositol polyphosphate-5-phosphatase E {ECO:0000313|Ensembl:ENSORLP00000000682.2};
GN Name=inpp5e {ECO:0000313|Ensembl:ENSORLP00000000682.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000682.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000682.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000682.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000682.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000682.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_004072102.1; XM_004072054.2.
DR AlphaFoldDB; H2L4I9; -.
DR STRING; 8090.ENSORLP00000000682; -.
DR Ensembl; ENSORLT00000000682.2; ENSORLP00000000682.2; ENSORLG00000000555.2.
DR GeneID; 101161245; -.
DR KEGG; ola:101161245; -.
DR CTD; 56623; -.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000158199; -.
DR HOGENOM; CLU_011711_5_5_1; -.
DR InParanoid; H2L4I9; -.
DR OrthoDB; 21647at2759; -.
DR TreeFam; TF323475; -.
DR Proteomes; UP000001038; Chromosome 9.
DR Bgee; ENSORLG00000000555; Expressed in animal zygote and 14 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR CDD; cd09095; INPP5c_INPP5E-like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR042478; INPP5E.
DR InterPro; IPR000300; IPPc.
DR PANTHER; PTHR46625; 72 KDA INOSITOL POLYPHOSPHATE 5-PHOSPHATASE; 1.
DR PANTHER; PTHR46625:SF1; PHOSPHATIDYLINOSITOL POLYPHOSPHATE 5-PHOSPHATASE TYPE IV; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 269..571
FT /note="Inositol polyphosphate-related phosphatase"
FT /evidence="ECO:0000259|SMART:SM00128"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 69141 MW; CB07F816EF067BAB CRC64;
MLDMRMSEDG ENGALHLSSL AKGNSVSHER QRLQTPLTAR RLAKQNEDVA GLAGGEVTTF
QPRPPSLPKL TRFVKSVSLE ETLRTRRIHN SQESLSDRAG TGSSTDSLKE DPPAPAVFAL
SGRDDDQDSP DFRGRGSSLS GSDGRPHSQQ SSSEERPAKV RLSPLQPRGP LPALERSFVS
APLRTSNRID RDCLDYKMPG KQKLGERSHS QLEDMGSDDI SVNTLKSFYS VLSPIRPQDM
RNRSFLEGSV LGSSALLGAE ELERYFPNRT LGIYIVTWNM QGERFLPANL NDLLLPTDSE
FAQDFYVVGV QEGCQDKREW EICIQETLGP HYVMLYAASH GVLYLNVFTR RDLIWFCSVP
EHSTVTTRII SQIKTKGALG IALTFFGTSF LFITSHFTSG DAKVYERVLD YNKIIEALTL
PKSLPDTNPY RSELSDVTTR FDQVFWFGDF NFRLNKDRAD VEAIMARTVG GDMSTLLEHD
QLSKELKDGS IFKGFKEAPI CFFPTYKFDI GCDKYDTTSK QRTPSYTDRI LFKSRNPKEI
KVVKYNSCSS VRTSDHRPVI GVFQVKVRPG RDNVPLCAGQ FDRGLYLEGI KRRMAARELR
RAKEGMTSPS TVCSIS
//
