ID H2L4R6_ORYLA Unreviewed; 1295 AA.
AC H2L4R6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Adhesion G protein-coupled receptor A1 {ECO:0000313|Ensembl:ENSORLP00000000765.2};
GN Name=ADGRA1 {ECO:0000313|Ensembl:ENSORLP00000000765.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000765.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000765.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000765.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000765.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000765.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR STRING; 8090.ENSORLP00000000765; -.
DR Ensembl; ENSORLT00000000765.2; ENSORLP00000000765.2; ENSORLG00000000620.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160175; -.
DR HOGENOM; CLU_005242_1_0_1; -.
DR InParanoid; H2L4R6; -.
DR TreeFam; TF331206; -.
DR Proteomes; UP000001038; Chromosome 15.
DR Bgee; ENSORLG00000000620; Expressed in animal zygote and 9 other cell types or tissues.
DR GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930:SF3; ADHESION G PROTEIN-COUPLED RECEPTOR A1; 1.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 676..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..757
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..854
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 234..324
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 673..981
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1144..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1295 AA; 141478 MW; 4D5C3691D0EF03CD CRC64;
MINLHSCLLS PLHALPFSIL IRSDYNTNGC LVTHALSLSF CPCRDLSNNR IGCLSPEMFI
DLRSLLKVNL SGNIFSTLTA GLFTSLVSLK VLHFSTETLF CDCHMKWLLT WAQSNSVRIG
NDTVCVFPTR LRGLAFHLLQ GQQLTCDSPL ELPLFQLIPS QRQLVFRGDR LPLQCTASYL
DPSVELQWHH NGHIVSTQES WDVYVEETLL HDCCLVTSEL ILSNIDVNAA GSWECVVTSS
RGNTSKLLEI VVAETSATYC PADRVNNNKG DYSWPKTLAG SLAFLPCTLP TFGSTTQKEK
KAWRQCDRAG RWAEEDYTQC PYTSEVTRGL HALSQTPING TNVQPLGQQL VAFTSRAVHF
SDVMDVIFVT HLVERLTRLM QKHKKLGDYV SDIASNMMLV EEHLLWMAQN EARACTRIVQ
CVERIADLAL AGDSQVISKV SANIALEAFV IRPSNFQGLS CTALQRAPSS ATLPYTPSHA
HLGKDRNQER NVKESPLLHL KCQTVNNSGS PARQLSKNSV AVASIHVPLA GAPASSSALQ
SVDNSTCRLQ FIVFRNGKLF PCTGNSSKLA DDGKRRSVST PVAFTKLDGC SRGSGVHSVT
IALRHFALGV DPTAAYWDFD LLDGHGGWRA EGCHITGSGG STTTIHCSHH SNFAVLMDLK
KVLSFPPYPG EFLHPVVYAC TAVMLLCLFA SIITYIVHHS AIRISRKGWH MLLNFCFHTA
LTFAVFASGI NRIKYPIICQ SVGFVLHYSS LSTMLWLGVT ARNIYKQVTK KPLQNQANDP
PPSSKQTLLR FYLVSGGVPL LICGVTAAVN IDVYGSGEQT PYCWMAWEPS LGAFFGPVAL
IVLVTCIYFL CAFIQLRRHP EKKYELKRLS EEQQRLAGID VPTHCHQGAE PGALTAHPSG
SSCPAGCPGV PINPALLANE HSFRAQLRTA AFTLFLFLVT WTFGALAVSQ GHFLDMIFSC
LYGAFSVTLG LFILIHHCAK RDDVWHCWCS CCPGRRPDAG SGAQGSAVAR PKVNVNGDTP
GHRHSHNHCH HDSQCQGKTV ISCSHGSLGH CKHAALPSSQ NHVTCLTPVT PCCATLRSQQ
LMEEEPAATH VLLHSDAEGC PPGVQLHPCL KSSTRTKSRH FGRRAGAAAC GAGSEREYAY
HISSSADGGS MHSSHTDSPH STHERHTHIC PHLAHEGRHE GHHACHAAAA ATHEPLACHN
PCHRHICCAK AELFPSLCQA EAGDTGVFLC GCGKVAEEEP THHHLEMHAP CRQSFPQTPP
NQNGILKGGL HEGLLYTSDS TGNIRTGPWK NETTV
//
