ID H2L555_ORYLA Unreviewed; 866 AA.
AC H2L555;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=SMB domain-containing protein {ECO:0000259|PROSITE:PS50958};
GN Name=LOC101171013 {ECO:0000313|Ensembl:ENSORLP00000000920.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000000920.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000000920.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000920.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000000920.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000000920.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; H2L555; -.
DR STRING; 8090.ENSORLP00000000920; -.
DR Ensembl; ENSORLT00000000921.2; ENSORLP00000000920.2; ENSORLG00000000744.2.
DR eggNOG; KOG2645; Eukaryota.
DR GeneTree; ENSGT00940000156034; -.
DR HOGENOM; CLU_012256_0_1_1; -.
DR InParanoid; H2L555; -.
DR OrthoDB; 1366859at2759; -.
DR TreeFam; TF330032; -.
DR Proteomes; UP000001038; Chromosome 11.
DR Bgee; ENSORLG00000000744; Expressed in intestine and 7 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0047429; F:nucleoside triphosphate diphosphatase activity; IBA:GO_Central.
DR GO; GO:0009143; P:nucleoside triphosphate catabolic process; IBA:GO_Central.
DR CDD; cd16018; Enpp; 1.
DR CDD; cd00091; NUC; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR Gene3D; 3.40.570.10; Extracellular Endonuclease, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
DR InterPro; IPR044929; DNA/RNA_non-sp_Endonuclease_sf.
DR InterPro; IPR020821; Extracellular_endonuc_su_A.
DR InterPro; IPR044925; His-Me_finger_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1.
DR PANTHER; PTHR10151:SF107; ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR SMART; SM00892; Endonuclease_NS; 1.
DR SMART; SM00477; NUC; 1.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR SUPFAM; SSF54060; His-Me finger endonucleases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00524; SMB_1; 2.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 46..89
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 90..134
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
SQ SEQUENCE 866 AA; 96891 MW; 433F5FF419E9D83B CRC64;
MNWAKTSQRK KKIIICVLAA SIVTLILGLG LGLGLELQSC KSKVPPGTSC RDRCYQPFDD
EIPGCRCDSN CAATGSCCFD FHDICTIPAQ QWECTKIRCG EKRLTQSKCH CSDDCLSAGD
CCTNYKHICQ GEKEWVEGEC EDLWPPSCPA GFKRQPLLLV SLDGLRAEYM QTWNTVMPVL
NKIRTCGTSA SYMQPAFPSK TFPNHYTIVT GLYPESNGLI DNTMYDPVFN ATFSLSNSEK
NNPDWYLGQP VWHTAKNQGL KSGTFFWPGS DVEINGSFPN IYKPYDGDVP FEERVLTVLK
WLQLPDNERP DFYTLYLEEP DKSGHSFGPV SGGIIISLQG VDKIIGQLMN GLKQIGLDRC
LNIVILADHG MEEISCDRKE AMQDLGVDTS LYVVTEGPFG RIRAKNVDTV LDSAALVASM
SCKKPDQKIT PYLKAHLPKR FHYADSRRIE DVNVLVEPKW LFERNPGSLT FCFGGNHGYD
NDADSMHALF LSYGPKFQFR TEVEPFSSIE LYNLMCDVLE ITPSENNGTH GSMNHALRNP
YHTPVHPVEQ SAPGQCPLVS LVPEDDLGCS CSSLEGNTIN SRLNLTAAQV SAAEKRHMLL
GRPQMLQPDQ SYCILHQEGF VSAYSHKVLM PLWSSFTVEK PTDITPLPPV ISDCLRADVR
LTPSQSPRCD LYETAGSLTP AFLFPPNLNV SADQQYDALL MSNVVPMYPR FKEIWDFFHN
SLLKKYAFLY NEINVVTGPV FDYDYNGCYD TPDQILESVP GTNISIPTHY FVLMTSCGDS
TQTVSSCTGQ LQTASFLLPH RADASESCKS SEEASRWVED HMWFHQARVR DVELITGLDF
YQGSKRPVAE LLKIKTRPTA AIHRKE
//
