ID H2L5J7_ORYLA Unreviewed; 778 AA.
AC H2L5J7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=slc6a5 {ECO:0000313|Ensembl:ENSORLP00000001073.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001073.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001073.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001073.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001073.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001073.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; H2L5J7; -.
DR STRING; 8090.ENSORLP00000001073; -.
DR Ensembl; ENSORLT00000001074.2; ENSORLP00000001073.2; ENSORLG00000000875.2.
DR eggNOG; KOG3660; Eukaryota.
DR GeneTree; ENSGT00940000154963; -.
DR HOGENOM; CLU_006855_4_1_1; -.
DR InParanoid; H2L5J7; -.
DR OrthoDB; 3084493at2759; -.
DR TreeFam; TF343812; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000000875; Expressed in bone element and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0015375; F:glycine:sodium symporter activity; IBA:GO_Central.
DR GO; GO:1903804; P:glycine import across plasma membrane; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0060012; P:synaptic transmission, glycinergic; IBA:GO_Central.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF315; SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 2; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 85856 MW; 9296B0B6C18B3643 CRC64;
MDCSEQREMS TPPGFIPAQQ PDGAAGIQSN KPDNAAACPA PAPHHHPAPQ LPPSCNESKT
FYPTEIKPGE PDSNKAYGTF KSAPPPVPGS AIVNSDFRKD SVGSARGGSA LCGDPLRATT
EQNNAVGNWT AMSQTTIILG ADGNMSVQPG VVAGAEDDDD EEGDENKARG NWSNKLDFIL
SMVGYAVGLG NVWRFPYLAF QNGGGAFLIP YLTMLGIAGI PIFLLEVSLG QFASQGPVSV
WKCIPALQGC GIAMLIISVL IAIYYNIIMC WTLYYLFASL KGSLPWANCR NEWNTVECKD
KDMLLLDSCI LRDRNAISVK NSTFCLSANA VGNLTKLLNV SIDANKTYVS PSEEYFKYNV
LHISKGIEYP GDIRWPLAGC LFLAWVIVYA SLAKGIKSSG KVVYFTATFP YVVLIILLIR
GVTLPGAGDG ILYFITPKWE KLSDAKVWKD AATQIFFSLS AAWGGLITLS SYNKFHNNCY
RDTVIVTCTN SATSIFAGFV IFSVIGFMAH ELKVPIEKVA DEGPGIAFVV YPEALTRLPL
SPFWAIIFFL MLLTLGLDTM FATIETIVTS VSDEFPKYLR KHKPVFTLIC CASFFILGFP
MITENGMYML QLVDTFAASY SLVIIAIFEL LGISYLYGLQ RFCADIEMMI GFQPNRFWRL
CWAFVTPTIL TGILGLSLYQ WKVMTYEDYT YPTWSMIMGW LMVICSVIWI PIMFLIKMYL
APGTIGERLK LVCSPQPDWG PFLMKHRGDR YKNMTDPLGT SSLGLKLPPK DFHLTSYQ
//
