ID H2L5R4_ORYLA Unreviewed; 909 AA.
AC H2L5R4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=Alpha-actinin-4 {ECO:0000256|ARBA:ARBA00040341};
DE AltName: Full=Non-muscle alpha-actinin 4 {ECO:0000256|ARBA:ARBA00042924};
GN Name=LOC101155449 {ECO:0000313|Ensembl:ENSORLP00000001150.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001150.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001150.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001150.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001150.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001150.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
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DR RefSeq; XP_011480503.1; XM_011482201.1.
DR AlphaFoldDB; H2L5R4; -.
DR Ensembl; ENSORLT00000001151.2; ENSORLP00000001150.2; ENSORLG00000000939.2.
DR GeneID; 101155449; -.
DR CTD; 81; -.
DR GeneTree; ENSGT00940000159343; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000001038; Chromosome 13.
DR Bgee; ENSORLG00000000939; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd21214; CH_ACTN_rpt1; 1.
DR CDD; cd21216; CH_ACTN_rpt2; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF425; ALPHA-ACTININ-4; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 37..141
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..256
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 804..839
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 436..470
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 909 AA; 104054 MW; C5E2E9AA39B2027B CRC64;
MVDYHAANNQ PSGGPQTYME QENDWDRDLL LDPAWEKQQR KTFTAWCNSH LRKAGTQIEN
IEEDFRDGLK LMLLLEVISG ERLPKPERGK MRVHKINNVN KALDFIASKG VKLVSIGAEE
IVDGNIKMTL GMIWTIILRF AIQDISVEET SAKEGLLLWC QRKTAPYKNV NVQNFHISWK
DGLAFNALIH RHRPDLIDYE SLRKDDPVTN LNNAFEVAEK HLDIPKMLDA EDIVNTARPD
EKAIMTYVSS FYHAFSGAQK AETAANRICK VLAVNQENEQ MMEDYEKLAS NLLEWIRRTI
PWLEDRTQQK TVNDMQAKQE DFRDYRTVHK PPKVQEKCQL EISFNTLQTK LRLSNRPAFM
PSEGRMVSDI NSAWHTLEGA EKGYEEWILS EIRRLERLEH LAEKFHQKAA IHESWTNGKE
AMLTQKDYET STLSEVKALL RKHEAFESDL AAHQDRVEQI AAIAQELNEL DYYDSASVNN
RCQKICDQWD TLGTLTHSRK DSLERTEKQL ESIDELYLEY AKRAAPFNNW MEGAMEDLQD
MFIVHNIEEI QGLIAAHEQF KSTLPEANKE REAIQAIQAE VQKIAQSNGI KLSGANPYTT
ITPRSIDDKW EQAMAMVPQR DKALQGELNK QNSNDTLRAT FAKQANVVGG YIQAKMEEIG
RISIEMNGTL EDQLTHLREY QQTILFFMPE INTLEGYHQH IQEALIFDNQ YTSYTMEHLR
VGWEQLLTTI ARTINEVENQ ILTRDAKGIS QEQLYEYRAS FNHFDKSTSG AEKGGRCDHT
GSLIAEEFKA CLISLGYDVE NEKQGDAEFT RIMSIVDPNN SGAVTFQAFI DFMSSETTDK
DSADQVIASF KILAGDKNYI MADELRRELP PDQAEYCIAR MAPYTGPDGV PGALDYMSFS
TALYGESDL
//