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Database: UniProt
Entry: H2L5R4_ORYLA
LinkDB: H2L5R4_ORYLA
Original site: H2L5R4_ORYLA 
ID   H2L5R4_ORYLA            Unreviewed;       909 AA.
AC   H2L5R4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Alpha-actinin-4 {ECO:0000256|ARBA:ARBA00040341};
DE   AltName: Full=Non-muscle alpha-actinin 4 {ECO:0000256|ARBA:ARBA00042924};
GN   Name=LOC101155449 {ECO:0000313|Ensembl:ENSORLP00000001150.2};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC   Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001150.2, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000001150.2, ECO:0000313|Proteomes:UP000001038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001150.2,
RC   ECO:0000313|Proteomes:UP000001038};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA   Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA   Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA   Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA   Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA   Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000001150.2}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001150.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   RefSeq; XP_011480503.1; XM_011482201.1.
DR   AlphaFoldDB; H2L5R4; -.
DR   Ensembl; ENSORLT00000001151.2; ENSORLP00000001150.2; ENSORLG00000000939.2.
DR   GeneID; 101155449; -.
DR   CTD; 81; -.
DR   GeneTree; ENSGT00940000159343; -.
DR   OrthoDB; 2872403at2759; -.
DR   Proteomes; UP000001038; Chromosome 13.
DR   Bgee; ENSORLG00000000939; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd21214; CH_ACTN_rpt1; 1.
DR   CDD; cd21216; CH_ACTN_rpt2; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF425; ALPHA-ACTININ-4; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 2.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          37..141
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          150..256
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          804..839
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          436..470
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   909 AA;  104054 MW;  C5E2E9AA39B2027B CRC64;
     MVDYHAANNQ PSGGPQTYME QENDWDRDLL LDPAWEKQQR KTFTAWCNSH LRKAGTQIEN
     IEEDFRDGLK LMLLLEVISG ERLPKPERGK MRVHKINNVN KALDFIASKG VKLVSIGAEE
     IVDGNIKMTL GMIWTIILRF AIQDISVEET SAKEGLLLWC QRKTAPYKNV NVQNFHISWK
     DGLAFNALIH RHRPDLIDYE SLRKDDPVTN LNNAFEVAEK HLDIPKMLDA EDIVNTARPD
     EKAIMTYVSS FYHAFSGAQK AETAANRICK VLAVNQENEQ MMEDYEKLAS NLLEWIRRTI
     PWLEDRTQQK TVNDMQAKQE DFRDYRTVHK PPKVQEKCQL EISFNTLQTK LRLSNRPAFM
     PSEGRMVSDI NSAWHTLEGA EKGYEEWILS EIRRLERLEH LAEKFHQKAA IHESWTNGKE
     AMLTQKDYET STLSEVKALL RKHEAFESDL AAHQDRVEQI AAIAQELNEL DYYDSASVNN
     RCQKICDQWD TLGTLTHSRK DSLERTEKQL ESIDELYLEY AKRAAPFNNW MEGAMEDLQD
     MFIVHNIEEI QGLIAAHEQF KSTLPEANKE REAIQAIQAE VQKIAQSNGI KLSGANPYTT
     ITPRSIDDKW EQAMAMVPQR DKALQGELNK QNSNDTLRAT FAKQANVVGG YIQAKMEEIG
     RISIEMNGTL EDQLTHLREY QQTILFFMPE INTLEGYHQH IQEALIFDNQ YTSYTMEHLR
     VGWEQLLTTI ARTINEVENQ ILTRDAKGIS QEQLYEYRAS FNHFDKSTSG AEKGGRCDHT
     GSLIAEEFKA CLISLGYDVE NEKQGDAEFT RIMSIVDPNN SGAVTFQAFI DFMSSETTDK
     DSADQVIASF KILAGDKNYI MADELRRELP PDQAEYCIAR MAPYTGPDGV PGALDYMSFS
     TALYGESDL
//
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