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Database: UniProt
Entry: H2L660_ORYLA
LinkDB: H2L660_ORYLA
Original site: H2L660_ORYLA 
ID   H2L660_ORYLA            Unreviewed;      4677 AA.
AC   H2L660;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   13-FEB-2019, entry version 50.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSORLP00000001304};
OS   Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
OC   Oryziinae; Oryzias.
OX   NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001304, ECO:0000313|Proteomes:UP000001038};
RN   [1] {ECO:0000313|Ensembl:ENSORLP00000001304}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001304};
RX   PubMed=17554307; DOI=10.1038/nature05846;
RA   Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
RA   Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
RA   Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
RA   Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
RA   Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
RA   Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
RA   Morishita S., Kohara Y.;
RT   "The medaka draft genome and insights into vertebrate genome
RT   evolution.";
RL   Nature 447:714-719(2007).
RN   [2] {ECO:0000313|Ensembl:ENSORLP00000001304}
RP   IDENTIFICATION.
RC   STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001304};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   STRING; 8090.ENSORLP00000001304; -.
DR   Ensembl; ENSORLT00000001305; ENSORLP00000001304; ENSORLG00000001057.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155288; -.
DR   OMA; TKHILKM; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001038; Chromosome 13.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IEA:Ensembl.
DR   GO; GO:0008345; P:larval locomotory behavior; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 1.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001038};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4001   4021       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4212   4232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4285   4307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4419   4439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4479   4501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4560   4582       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       43    106       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      108    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      350    565       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      783    977       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1110   1321       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      230    250       {ECO:0000256|SAM:Coils}.
FT   COILED     1685   1707       {ECO:0000256|SAM:Coils}.
FT   COILED     1848   1868       {ECO:0000256|SAM:Coils}.
FT   COILED     2657   2677       {ECO:0000256|SAM:Coils}.
FT   COILED     3347   3374       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4677 AA;  532601 MW;  2CAB924AE8F46008 CRC64;
     MAEGGEGEEE IQFMRTMANY EGGAVCSQAR SLWRLEPLRI WSGSHMKWGQ SFRIRHITTG
     RYLCLDEEKG LMVVDPEKAN TKLSAFCFRA SKEKVDVAQK RDVEGMGIPE IKYGESMCFV
     QHVSTGLWLT YAALDAKAAR LGMMKRRVIL HQEGHMDDAL TVSRSQTEES QAARMIYSTM
     GLFRQFIRGL DSLSGKSKSL GTVSLPLAGV ILSLQDLIFY FRPPEEELEH EEKQTKLRSL
     RNRQNLFQEE FQGMITIVLE CIDRLNVYNT AAHFSEFAGE EAAESWKEIV NLLYELLSLI
     RGNRSNCALF CDNLDWLVSK LDRLEASSIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD
     KHGRNHKVLD VLRSLCVCNG VAVRSNQNLI TENLLPGRDL LLQTNIVNYA TVRPNIFLGT
     CEGSTQYKKW YYEMMVDYVE PFMTAQATHL RVGWAMTEGY SPYPGGGEGW GGNGVGDDLY
     SYGFDGLHLW STVPRQVASP NAHTLAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNV
     DGLFFPVISF SAGVRARFLL GGRHGEFKFM PPPGYAPCYE AVLPRERMRI EPIKEYKHDF
     EGVRNLLGPT LSLTHTSFTP CPVDTVQIVL PPHLERIREK LAENIHELWA ITRIEQGWTY
     GQVLQFRDDN KKLHPCLVDF QNLPEPERNY NLQMSGETLT LLALGCHVGM GDEKAEENLK
     KIKLPKYVMS NGYKPAPLDL NHVKLTPNQN QLVEKLAENG HNVWARDRVR QGWTYSIVQQ
     DIVNKRNPRL VPYNLLDERT KKTNRDSVNN AVRTLIGYGY NIEPPDQEGG HGLENIRGDK
     VRIFRAEKSY AVTQGKWYFE FEAVTTGEMR VGWARPSVRS DTELGADELA YVFNGNKAQR
     WHIGNEPFGR QWLSGDVVGC MIDLIDMNIM FTLNGEMLIS DSGSEMAFKD IEIGEFIPVC
     ALGLSQVGRI NLGQNVSSLR YFAICGLQEG FEPFAINMKR DITMWFSKGL PQFVPVPTDH
     NHIEVSRVDG TVDSAPCLKL THKTFGSQNA NTDMMFLRLS MPVQFHETFK FPAGTTPLTR
     ALTIPEDEVV VVEPDSEFEV LKKSASRKEQ EEDKKEPSVP KEVSVENEKD TASEKGKKKF
     FSKAKKAAMT PLAPPPAPPT VPRLVEDVVP DDRDDPEIIM DTTTYYYSVR IFAGQEPSAV
     WIGWVTPDFH QYDQNFDLSK VRNVTLTVGD DRGNIHDMKH SNCYMVWGGD LVSNQQTRFS
     QEDMVVGCLV DLATGLMTFT ANGKEINTFY QVEPNTKLFP AVFIQPTNQN MAQLELGKLK
     NIMPISAAMF RSERKNPVPQ CPPRLDVQML TPVIWSRMPN HFLNPEVGKI SERLGWMVEC
     TEPLIMMALH IPEENCIDIL ELSERQDLMK FHYHTLMLYC AVCALGNNRV AHALCSHVDE
     SQLFYAIENT FLPGPLRSGY YDLLISIHLE SAKRARLGTN REFIIPMTEE TLSIKLYPDT
     KKSHSLPGVG LTTCLRPKLH FSSINFVGTD PDLYTLSPTF PLQQELKTRA ISMLTEAVMD
     GSQAMRDPVG GSVEFHFVPI LKLISTLLMM GIFNDEDTMH ILKMIDPNVF SGKEEEEEGE
     KEEEAPKEGE AQVDEEEEEE LEDEGVGEDE ELKEPEKEEG EEPKEDAEEG EKEKAEKLKE
     GKVDGEKAEE EKEAEAVEEE AKEEEEAPEE GLLQMKLPES VKLQMCTLLQ YFCDCELRHR
     VETIVAYSDN FVQGVKSNQR VRYNQLMRAF TMSAAETARK TREFRSPPQD QVLLLTNFKN
     CPEDEDCPVP EEIRDTLTGF HNDILLHCIH IEEEVVEEEV DTSLRGRLLS LVDKVKSLRR
     KKEEGEEEEK PEVEEEPKLT LQELISHTMI HWAQESFIQN PELVRLMFSL LHRQYDGIGE
     LIRALPKAYA INAVSVQDTM DLLECLGQIR SLLIVQMGPE EERLMIQSIN IMNNKVFYQH
     PNLMRALGMH ETVMEVMVNV LGGGGDSKVI RFPQMVTNCC RFLCYFCRIS RRNQRAMFDH
     LSYLLQNSGI GLMSGSTPLD VAAASCIDNN ELALALQEQD LEMVVTYLAG CGLQTCPMLL
     SKGYPDIGWN PCGGEKYLDF LRFAVFVNES VEENANVVVR LLIRRPECFG PALRGEGGNG
     LLAAMEEAIK ISEDPARDGP TVKKDRRFLI QAGKGEALRI RAILRSLVPI EDLVGVISLP
     VQIPAYGKGQ IIEPKMSASF VPDHKASMVL FLDRVYGIDN QDFLLHVLEV GFLPDMRAAA
     SLDTVAFSTT EMALALNRYL CSAVLPLLTK CAPLFAGTEH RAIMIDSMLH TIYRLSRGRA
     LTKAQRDVIE ECLMSLCYLR PSMLQHLLRR LVFDVPILNE YAKMPLKLLT NHYERCWKYY
     CLPNGWANFG VTSEEELHLS RKLFWGIFES LAHKKFDAEL FKIAMPCLCA IAGAIPPDYV
     DATYSSNTEK KASVDAEGNF DPKPVETTTI IPERLDAFIN KYAEHTHDRW AFEKIQNNWT
     YGEVLDENGK THPMLRPYKT FSEKDKEIYR WPIKESIKAM LAWEWTLEKA REGEGEVEKK
     ATSQKISQTA QATYDPSHGY NPQPIDITGM ALSRELQSMA EQLAENYHNT WGRKKKLELQ
     AKGGTHPLLV PYDTLTAKEK ARDREKAQDL LKFLQLNGYA VTGLKDMEQD ISSIEKRFAY
     GFLQKLLKWM DIAQEFIAHL AVVSSGRVEK SPHEQEIKFF AKILLPLVNQ YFKNHCLYFL
     STPAKVLGSG GHSSNKEKEM IAIFCKLAAL VRHRVSLFTD AGAVVNCLHI LSRSLDAVKG
     VSQNINYTTN ALLPVLTSLF DHIAQHQFGD DVMVDDLQIS CYRLMCSIYS LGTVKTPHVE
     QRPALGECLA HLAAAMPVAF LEPALNEFNA FSVYTTKTPR ERTLGIPNQV EELCPDIPEL
     EVLIKEIHDL SESGARYTEM PHVIEITLPM MCNYLPRWWE RGPENFPEQE GQLCTSVTSE
     HLNQLLGSIM KIVVNNLGID EASWMKRLAF AQPIVSRAKP EMLKSHFIPT MEKLKKRSSK
     VVAEEEHLRM EGKSEVDSEN GTIRDEFAVL CRDLYALYPL LIRYVDNNAR WLTCPDPDAE
     ELFRMVGEVF IFWSKSHNFK REEQNFVVMN EINNMSFLTA DSKSKMSKGG SEQERSKKKK
     RGDRYSVQTS LIVAALKKML PIGLNMCSPA DQELINVAKI RYSLKDTDEE VREFLHNNLH
     LQGKVEDPAM RWQMSLYKER SGNTEDAEDP EKVVKRVQEV SAVLYHIEQT EHPYKSKKMV
     WHKLLSKQRR RAVVACFRMT PLYNIPHRAI NMFLDAYKRN WLENEGYSFE DRMIDDLSKA
     LEEEEEEEEE TERKPDPLHQ LILHFSRTAL TEKKLDVDHL YMSYADIMAK SCHIGEEDEG
     GEQEGEEPAF EVRQTEMEKE MEKQRLLYQQ SRLHNRGAAE MVLQMISACK EPGVMVSSTL
     KLGISILNGG NSDVQQKMLE YLKDKKDVGF FLSVQALMQT CVLDLNAFER QNKAEGLGMV
     SEEGSEKVMA DDEFTCDLFR FLQLLCEGHN NFQNYLRTQT GSTTTINIII CTVDYLLRLQ
     ESISDFYWYY SGKDIIDGPG KRNFSKAMTV AKQVFNSLTE YIQGPCTGNQ QSLAHSRLWD
     AVVGFLHVFA HMMMKLAQDS SQIGLLKELL DLQKDMVVML LSLLENIVNG TIARQMVDML
     VESSSNVEMI LKFFDMFLKL KDIVASDAFR DYVTDPRGLI SKKDFSKAMD SQKQYSPSEI
     QFLLSCSEAD ENEMINFEEF ADRFQEPAKD IGFNIAVLLT NLSEHVPHDT RLQNFLEQAE
     SVLNYFRPFL GRIEIMGASR KIERIYFEIS EANRNQWEMP QVRESKRQFI FDVVNEGCES
     EKMEMFVNFC EDTIFEMNIA ASISEPEGEP EEKDDDEEEE EGGAEEESGE GEEGNGEAHV
     PESTSAFADF LKSVMNFFHM FTFRNLRRRY RKLRRMTIKE MVIGLVTFIY TVLMGILIFV
     YNICKGFFTL IWKALFGGGL VEGAKKMTVT EILASMPDPT QDEVHDELPP EPGAREVQDA
     EGGAEHLDTV GGEEEEEDGE EGEGGRLPGF NTPGGLGDFG ETTTEEPPTP EGTPLLKRKL
     VENGEKADKA EPVAEVKEEE PEKKEEPEIE EEKAVKTKAK KEKKPAGEGF ELWNELEVQR
     IKFMNYLSRN FYNLRFLALF IAFALNFILL FYKFEGSGLF EGSGLFEGSG AEEEGSGLEE
     GGEDEDEEGP LYYFLEESTG YMEPALAFLS ISHTIISFLC IIGYNCLKVP LVIFKREKEL
     ARKLEFDGLY VTEQPEDDDI KGQWDRLVLN TTFPNNYWDK FVKRKVLDKY GDIYGRERIA
     ELLGMDLASL DVSAMTHGKK PEPDTSMFSI TSIDIKYQIW KFGVVFTDNT FLYLVWYMVM
     SVLGHYNNFF YACHLLDIAM GVKTLRTILS SVTHNGKQLV MTVGLLAVVV YLYTVVAFNF
     FRKFYNKSED EDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDE YELYRVVFDI
     TFFFFVIVIL LAIIQLIIDA FGELRDQQEQ VREDMETKCF ICGIGSDYFD TTPHGFETHT
     LEEHNLANYF FLMYLINKDE TEHTGQESYV WKMYQERCWD FFPAGDCFRK QYEDQLG
//
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