ID H2L711_ORYLA Unreviewed; 1611 AA.
AC H2L711;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Cytoplasmic linker associated protein 1 {ECO:0000313|Ensembl:ENSORLP00000001619.2};
GN Name=CLASP1 {ECO:0000313|Ensembl:ENSORLP00000001619.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001619.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001619.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001619.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001619.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001619.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR STRING; 8090.ENSORLP00000001619; -.
DR Ensembl; ENSORLT00000001620.2; ENSORLP00000001619.2; ENSORLG00000001312.2.
DR GeneTree; ENSGT00940000154817; -.
DR HOGENOM; CLU_005060_0_0_1; -.
DR InParanoid; H2L711; -.
DR Proteomes; UP000001038; Chromosome 2.
DR Bgee; ENSORLG00000001312; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0045180; C:basal cortex; IBA:GO_Central.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0043515; F:kinetochore binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0040001; P:establishment of mitotic spindle localization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..236
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 172..210
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 309..545
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 881..1112
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1367..1601
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 242..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1151..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..852
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1611 AA; 176886 MW; C26AF6F551C63FB8 CRC64;
MEEQGPVSMD HLLEQVMHKD LGRRLQVGQE VTELLMSEER CPDLEQDQAA LDRLVDSVAS
SWVNSSNFKV VLLGMDILSA LVGRLQERFR TQVGTALPSL IDRLGDSKDQ VREQDQALLL
KIMDQAANPQ YVWERMIGGF KHKNNRTREG LCLCLISTLN VFGSQSLTLS KIVPHICNLL
GDPTSQVRDG AMNCLVEIYR HVGERVRMDL GKKGLPQSRL NMIFSKFDEV QCSGNMVLSP
MSDKNFEDDD SVDGGRSSSS SKATSLSGRK VVSMGSFRRP ASANKSAATA GAVDEEDFIQ
AFEDVPSIQI YSNREVEEAL TKIRDVLSDD KRDWELRVAA LKKLRSLLLA GAAEFDGFLQ
QLRLMEAAFK LSAKDLRSQV VREACITLGY FSLVLGGRFD HAAEAVMPTL LNLVPNSAKV
MATSGVAAIR LILRHTHFPR LIPIITSNCT SKAVAVRRRC FEFVDLLLHE WQASSLERHV
AVLMETIKKG IHDADAEARS VARKCYWGFH AHFSREAEQL FQALESSYQK ALQAHLRSGD
SLMSLPASDR SSSSSQESLN RPLSVKNSVG SSRSKAVPST RKPATASSPG SLHRSRSDVD
VNAAASANAR TRMSAVSSAV PSSPFSSASA LPPGSYASLD ASRSVHADGR VRTRRTSSGN
SPSLTDSRGR SRGKVVSQSQ PGSRSGSPGR LLTSTYGRIP RPTMGAPSPQ TPTSISSSYS
EKNRPRGHRS QGCSRDNSPT RSGAARSRIP RPSMSQGCSR ETSRESSRDT SPARGFSPLV
SRRHSRSTSA LSSAECCSDR LSHQARISAS VNAMRILNTG TEVEAAVADA LLLGDSRSKR
RPARRRFESP GMYSDDDANS DASSACSERS YSSRNGGVTP HYMRQMEDVA EVLNHCASAN
WSERKEGLLG LQNLLKSQRM LSRVELKRLC EIFTRMFADP HSKVFSMFLE TLVDFVVLHR
DDLQDWLFVL LTQLLKKMGA DLLGSVQAKV QKALDVTRES FPYEQQFNIL MRFIVDQTQT
PNLKVKVAIL RYIEALARQM DPADFVNSSE TRLAVSRIIT WTTEPKSSDV RKTLQSWAGE
EPSGRAGTVA SLPGEGNLEE RCKQAAQVVL IALFELNTPE FTMLLGALPK TFQDGTTKLL
HNHLRSASTA VAMAAPSNSA TRTPPRAPGS RGSPLTSPTN CSHGSLSSSR MWAWSADGLS
TFPPPSSSLP PPPAAVSSLR VVRRACSPST MEYDSENLNS EEIYSSLRGV TEAIQNFSFR
SQEDLMEPLR REAGGAVPFD SDPRSCGEAV EGGRTALDNK TSLLNTPSAR SFTGPRFRDY
NPGNYTDGPG SLDKAALYED GGEPRRDARR QECVENKILN PKSFPACPTE QLELVGQLLK
ELSQGQGGEK GPEERRGTLL ELLKVAREDA LMVWDEHFKT MLLLLLETLG DKDHTIRALA
LRVLKEILRN QPARFKNYAE LTIMKALEAH KDSHKEVVRA AEEAASTLAG SIHPEQCIKV
LCPIVQTADY PINLAAIKMQ TRAIERISKE PLHQLLPDII PGLLQGYDNT ESSVRKASVF
CLVAIYSVIG EELKPYLAQL TGSKMKLLNL YIKRAQTSTS NSSSSSDISS Y
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