ID H2L767_ORYLA Unreviewed; 478 AA.
AC H2L767;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Keratin 5 {ECO:0000313|Ensembl:ENSORLP00000001676.2};
GN Name=LOC101168116 {ECO:0000313|Ensembl:ENSORLP00000001676.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000001676.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000001676.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001676.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000001676.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000001676.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; H2L767; -.
DR Ensembl; ENSORLT00000001677.2; ENSORLP00000001676.2; ENSORLG00000001350.2.
DR GeneTree; ENSGT00940000161090; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Bgee; ENSORLG00000001350; Expressed in gastrula and 12 other cell types or tissues.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 106..417
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..130
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 159..242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 315..395
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 460..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 51924 MW; AA59F47823881586 CRC64;
MSVQTVSRTS FRSSSGGRAS GSGLMSSGFS SKSSAAGMSG GFQSGSIRRS GGFSSSSAYG
GSSGFGMSSA GGPSLPTITN VQFNQSLLAP LNLEIDPNIQ IVRSQEKDQI KNLNNRFASL
IDKVRFLEQQ NKMLDTKWSL LQDQTTSRSN IDAMFEAYIA NLRRQLDGLG NEKNKLEGEL
RNMQGSVEDF KKKYEDEINK RASVENEFVL LKKDVDAAYM GKIELEAKVD ALQDEINFLR
SIYEMELSEL QGQIKDTSVI VEMDNSRHLD MDAIVAEVRA QYEEIANNSR AEAEKWYQQK
FQEMQVSATQ AGDDLRNTKS EIAEINRMIS RIQNEIEAVK GQRSNLENQI AEAEERGEMA
VKDAKQRIRD LEEALQKAKQ DMARQVREYQ ELMNVKLALD IEIATYRKLL EGEELSGGGS
GFGGGMGYGM GGGGGFSSGG GAGGYGGGAG GFGGMGGGMS SGGSMSSRSS LRLSSARY
//
