ID H2L877_ORYLA Unreviewed; 1152 AA.
AC H2L877;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=SAM domain-containing protein {ECO:0000259|PROSITE:PS50105};
GN Name=ppfia3 {ECO:0000313|Ensembl:ENSORLP00000002047.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002047.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002047.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002047.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002047.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002047.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2L877; -.
DR Ensembl; ENSORLT00000002048.2; ENSORLP00000002047.2; ENSORLG00000001644.2.
DR eggNOG; KOG0249; Eukaryota.
DR GeneTree; ENSGT01050000244900; -.
DR HOGENOM; CLU_006923_0_0_1; -.
DR TreeFam; TF314207; -.
DR Proteomes; UP000001038; Chromosome 8.
DR Bgee; ENSORLG00000001644; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF4; LIPRIN-ALPHA-3; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038}.
FT DOMAIN 798..864
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 923..980
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1004..1073
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..125
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 169..203
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 241..499
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 612..653
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 545..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..781
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 130163 MW; F352FE6FAC96404D CRC64;
MMCEVMPTIS EDGRGGGGGG SDEGGSTGNL ESLMVNMLTE RERLLESLRE TQDSLGTAHL
RLRELGHEKE SLQRQLSIAL PQEFAVLTKE LNLCREQLLE REEEIAELKA ERNNTRLLLE
HLECLVSRHE RSLRMTVVKR QAQSPAGVSS EVEVLKALKS LFEHHKALDE KVRERLRVAL
ERVSALEEEL HTSSQEVVTL KEQVKRRQQG LEPGKEVTRL PNGPSSILDD GDTDRQREGE
IERQRSELGQ LKERLALMCR QVGEIEEQLT SARRELARSE EANQKLQRDL KEALCQREDM
EERITTLERR YLSAQREATS LHDIKDKLEN ELASKESLHR QSEEKNRQLQ ERLDDAKQKL
QQTLQRAETL PEIEAQLAQR VAALNKAEER HGNFEERLRQ MEAQLEEKNQ ELQRARQRER
MNDEHNKRLS DTVDKLLSES NERLQLHLKE RMAALEEKNA LSEELSNMKK LQDDVLANKD
QLIAELERLQ LELDQLRARP GGSYSSRSLP GSALELRYSH GCGSLPAGST THLDPFSNTS
AMAVGRRRDR ARWSSAREDS SKYPDWESGA LSGTGYEPGM DIGCSDDDDD AERHFGSGLL
SPSGQTDVQT LAIMLQEQLE AINKEIKLIQ EEKENTELRA EEIESRVSVA LDNSAGQGFI
PSSITSSTLA SPSPPSSGTS TPRLPHSPAR EIDRQVPRYQ PPRLCKQLLH GSSSNSSQDS
LHKSSKKKSI KSSIRGFFGK KEKGRMGQPG REGSVSAGKE LEDKAGRTLG PADKDRRSKK
KHELLEEACR QGLPFASWDG PTVVSWLELW VGMPAWYVAA CHANVKSGAI MANLSDTEIQ
REIGISNPLH RLKLRLAIQE MVSLTSPSAP ASTRSSTSNV WMTHAEMESL NAATKPPVTT
IIWACPFQIL AYGDMNHEWV GNEWLPSLGL PQYRSYFMES LVDARMLDHL TKKELRGQLK
MVDSFHRVSM HYGIMCLKRL NYDRKELERR REESVHQNKD VMVWSNERVM CWVQSIGLKE
YADNLRESGV HGALLALDDT FDYTDLALLL QIPNQNTQAR QLLEQEYNSL ISMGTERRPD
EDGAKTFTRS PSWRKMFREK DLRGVTSDSS ETLPANFRAS AISTPSVTLR KVQSEGDSGA
RGESASVRTY SC
//
