ID H2L8I4_ORYLA Unreviewed; 1269 AA.
AC H2L8I4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Regulatory associated protein of MTOR complex 1 {ECO:0000313|Ensembl:ENSORLP00000002157.2};
GN Name=RPTOR {ECO:0000313|Ensembl:ENSORLP00000002157.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002157.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002157.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002157.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002157.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002157.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR AlphaFoldDB; H2L8I4; -.
DR Ensembl; ENSORLT00000002158.2; ENSORLP00000002157.2; ENSORLG00000001734.2.
DR eggNOG; KOG1517; Eukaryota.
DR GeneTree; ENSGT00640000091541; -.
DR HOGENOM; CLU_001136_3_1_1; -.
DR TreeFam; TF105729; -.
DR Proteomes; UP000001038; Chromosome 1.
DR Bgee; ENSORLG00000001734; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 5..145
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 630..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1269 AA; 142334 MW; A56E707CEDAAD798 CRC64;
MDSDLLHSPA VGLAEEEEAD MNDWKLPLTF MKKRHLEKIE GSKALAQSWR MKDRARYKQS
LDPTVDEVKK LCTSLRRNAK EERVLFHYNG HGVPRPTVNG EIWVFNKNYT QYIPLSIYDL
QTWMGSPSIF VYDCSNAGII VKSFKQFALQ REQELEVAAI NPSHPLAQMP LPPSMKNCIQ
LAACEASELL PMNPDLPADL FTSCLTTPIT IALRWFCMQK SAKLVPGVTL DLIEKIPGRL
NDRRTPLGEL NWIFTAITDT IAWNVLPRDL FQKLFRQDLL VASLFRNFLL AERIMRSYNC
TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ LPTIMEGTAF RPSEFFTQQL TAFEVWLTMG
VENRNPPEQL PIVLQVLLSQ VHRLRALELL GQFLDLGPWA VSLALSVGIF PYVLKLLQSS
ARELRPLLVF IWAKILAVDS SCQADLVKDN GHKYFLSVLA DNYMPAEHRT MAVFILAVIV
NNYSTGQEAC LQGNLIANCL EQLSDPHPLL RQWVAICLGR IWQNFDPARW CGVRDSAHEK
LYTLLSDPIP EVRCAAVFAL GTFVGNSGER TDHSTTIDHN VAMMLAQLIN DGSPVVRKEL
VVALSHLVVQ YESNFCTVAL QFIEEEKNYS VPSPANTTEP GNLTPVRDSP AIPRLRSVNS
YTNIRAVTTA RNLNKSLQNL NLNEEGGPAA FSPGNLSTSS SASSTLGSPD NDEYILSFET
IDKMRRVSSY SSLNSLIGVS FNSVYTQIWR VLLHLAADPF PEVSDLAMKV LNSIAYKATM
NARPQRILDS ASLTKSAPAS PTSKGTLIHQ AGGSPPMPST SSSSLTNDVP KPPNREQPAT
RPPYTPTLGG QAPHSHQFPR TRKMFDKGPE QGAEDGDEPV GHRNYVSLSL QTGLCDWSAK
YFAQPVTKIP EEHDLESQVR MERQWRFLRN ARVRRQSRVI TQRGISRLDD QIFINRNPGV
PSVVKFHPFN TCIAVADKDS ICFWDWEKGE RLDYFYNGNP RYTRITAMQY LNGHDCSLLL
TATDDGALRI WKNFADQKNP EMVTAWQGLS DMLPTTRGAG MVVDWEQETG LLMTSGDVRI
IRIWDTDREM KVQDIPTGAD SCVTSLSCDS HRSLVVAGLG DGSVRVFDRR MGPNECRVMT
YREHGAWVVK AHLQKEADGN IISVSVNGDV RFFEPRTPDS INVLQTVKGL TALDIHPQAN
LFACGSMNQF IAVYNSNGDV ISNIKYYDGF MGQRIGAISC LAFHPYWPHL AVGSNDYYMS
IYSAEKRLR
//
