ID H2L8R7_ORYLA Unreviewed; 1200 AA.
AC H2L8R7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Integrin, alpha 11a {ECO:0000313|Ensembl:ENSORLP00000002247.2};
GN Name=itga11a {ECO:0000313|Ensembl:ENSORLP00000002247.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000002247.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000002247.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002247.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000002247.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000002247.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_004067003.2; XM_004066955.2.
DR AlphaFoldDB; H2L8R7; -.
DR STRING; 8090.ENSORLP00000002247; -.
DR Ensembl; ENSORLT00000002248.2; ENSORLP00000002247.2; ENSORLG00000001800.2.
DR GeneID; 101167187; -.
DR KEGG; ola:101167187; -.
DR CTD; 541475; -.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000155465; -.
DR HOGENOM; CLU_004111_2_1_1; -.
DR InParanoid; H2L8R7; -.
DR OrthoDB; 3816176at2759; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001038; Chromosome 3.
DR Bgee; ENSORLG00000001800; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF21; INTEGRIN ALPHA-11; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1200
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017101953"
FT TRANSMEM 1150..1174
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 34..93
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 176..357
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 476..539
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 541..599
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 603..663
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1200 AA; 134693 MW; 0F4EB116A68C2995 CRC64;
MHARRSRHME YYCFLLLWIC SQQFGLHDCF NIDTKTPRII KGPKQAQFGY TVQQHVAAGG
EKWLLVGAPY EMNGPYQTGD IYKCSLSKGT NGNGCSKLNL GRISLTNVSE RKEKMRLGMT
LTSNPKDNSF VACGPLWSYE CGNSYYSTGI CSRVNESFKF SRTIAPAFQR CETYMDIVIV
LDGSNSIYPW YEVQAFLINI LQKFHVGPGQ IQVGVVQYGE KVVHEFKLSD YKSVEEVVKR
ARSINQRGGE ETNTALGINT ARSEAFKQGG RRGAKKVMIV ITDGESHDSA DLKQAIEDSE
KDDITRYAIA VLGYYNRRGI NPEAFLSEIK YIASDPDDKH FFNVTDESAL KDIVDALGER
IFSLEGTSKN GTAFGLQMSQ AGFSAHSVED GTVVGAVGAY DWNGAVLKET RQGKVVPPKL
SYRQEFPEEL KNHGAYLGYT VTSVMSARNG RLLVAGAPRF NHTGKVIIFT LKNSGNLTIL
HSLNGHQIGS YYGSEIAPMD IDGNGVTDNL LVAAPMFFSG GLEKGKVYIY RITELNQFIF
EGTLEIHNGG QNARFGSSLA PVPDLNGDGF NDLVVGAPLE DDHKGAIYVF FSQNSRILRK
YKQRIAAADL APGLQYFGRS IHGVMDMSDD GLVDLAVGSL GAAVILRSQT VVRIYTSVRF
EPTKINIFVK DCQRGGKDVT CMSAIVCFNI TARTAVSLDR EIGIKYNVSI MERRFNPRAL
LDNPSKMQPQ NLTLFPGLDT CEHIFFHVME TTDYARPVVF AVQVGLQDPE NEPVLDDSWP
TLLRTELPFW NGCDEDDHCT PDLSLQSTTD LMTQRQFCAQ HVKSLGAFCR HQSEDKMEEP
LRVLEGKRRK MVVDIKLENK GENAYNALFR ATYSANLLFS SLIVKDKSDI KIECYISDKT
KNEKICNVSA PFMRAKTQVS FRLEFEFSHT ILFDHVRVVL QASSDGEEMN KADNFKVIYY
PLKYEGDLLF TRHSDTTRYE IKPELSLEEP GITGPPFNLT FQIHNLGLFP VRDLQLDIEI
PQMTKNGNQL LQISDFYFDQ RDGTHCSLPQ HVAHSRASPE DLSRFSRLNR SNTLILPIHC
TINVASKKEF AVRISGALKI DTLHTLKFKV LELVTSASME LPSSSPMLLH EERPIRHIIL
EIRKQGDYRI PIWIIIGSTL GGLLLLALLS LALWKLGFFR RQKRRDKEEP ETNGKVAEER
//
